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B淋巴细胞记忆：基质细胞补体和FcγRIIB受体的作用

B lymphocyte memory: role of stromal cell complement and FcgammaRIIB receptors.

作者信息

Barrington Robert A, Pozdnyakova Olga, Zafari Mohammad R, Benjamin Christopher D, Carroll Michael C

机构信息

Center for Blood Research and Department of Pathology, Harvard University, Boston, MA 02115, USA.

出版信息

J Exp Med. 2002 Nov 4;196(9):1189-99. doi: 10.1084/jem.20021110.

DOI:10.1084/jem.20021110
PMID:12417629
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2194107/
Abstract

To dissect the influence of CD21/CD35 and FcgammaRIIB in antigen retention and humoral memory, we used an adoptive transfer model in which antigen-primed B and T lymphocytes were given to sublethally irradiated wild-type mice or mice deficient in CD21/CD35 (Cr2(-/-)) or FcgammaRIIB receptors (FcgammaRIIB(-/-)). Cr2(-/-) chimeras showed impaired memory as characterized by a decrease in antibody titer, reduced frequency of antibody secreting cells, an absence of affinity maturation, and significantly reduced recall response. The impaired memory in Cr2(-/-) chimeras corresponded with the reduced frequency of antigen-specific memory B cells. Interestingly, FcgammaRIIB(-/-) chimeras showed a differential phenotype with impaired splenic but normal bone marrow responses. These data suggest that CD21/CD35 on stroma, including follicular dendritic cells, is critical to the maintenance of long-term B lymphocyte memory.

摘要

为剖析CD21/CD35和FcγRIIB在抗原保留和体液免疫记忆中的作用，我们采用了一种过继转移模型，即将经抗原致敏的B淋巴细胞和T淋巴细胞给予亚致死剂量照射的野生型小鼠，或缺乏CD21/CD35（Cr2(-/-)）或FcγRIIB受体（FcγRIIB(-/-)）的小鼠。Cr2(-/-)嵌合体表现出记忆受损，其特征为抗体滴度降低、抗体分泌细胞频率减少、缺乏亲和力成熟以及回忆反应显著降低。Cr2(-/-)嵌合体中记忆受损与抗原特异性记忆B细胞频率降低相对应。有趣的是，FcγRIIB(-/-)嵌合体表现出不同的表型，脾脏反应受损但骨髓反应正常。这些数据表明，包括滤泡树突状细胞在内的基质上的CD21/CD35对于长期B淋巴细胞记忆的维持至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f19a/2194107/d9ab9fee43b8/20021110f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f19a/2194107/64b63ea99c4e/20021110f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f19a/2194107/bae973105218/20021110f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f19a/2194107/3b086339cf5b/20021110f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f19a/2194107/b3d182acc402/20021110f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f19a/2194107/d9ab9fee43b8/20021110f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f19a/2194107/64b63ea99c4e/20021110f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f19a/2194107/bae973105218/20021110f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f19a/2194107/3b086339cf5b/20021110f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f19a/2194107/b3d182acc402/20021110f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f19a/2194107/d9ab9fee43b8/20021110f5.jpg

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