Duke University, Biomedical Engineering Department, Durham, North Carolina.
J Biophotonics. 2019 Jun;12(6):e201800383. doi: 10.1002/jbio.201800383. Epub 2019 Mar 7.
Recent studies have demonstrated that extended imaging depth can be achieved using dual-axis optical coherence tomography (DA-OCT). By illuminating and collecting at an oblique angle, multiple forward scattered photons from large probing depths are preferentially detected. However, the mechanism behind the enhancement of imaging depth needs further illumination. Here, the signal of a DA-OCT system is studied using a Monte Carlo simulation. We modeled light transport in tissue and recorded the spatial and angular distribution of photons exiting the tissue surface. Results indicate that the spatial separation and offset angle created by the non-telecentric scanning configuration promote the collection of more deeply propagating photons than conventional on-axis OCT.
最近的研究表明，使用双轴光学相干断层扫描（DA-OCT）可以实现扩展的成像深度。通过以倾斜角度照明和收集，可以优先检测来自大探测深度的多个向前散射光子。然而，增强成像深度的机制需要进一步的研究。在这里，我们使用蒙特卡罗模拟研究了 DA-OCT 系统的信号。我们对组织中的光传输进行建模，并记录了从组织表面出射的光子的空间和角度分布。结果表明，非远心扫描配置产生的空间分离和偏移角促进了比传统共轴 OCT 更深传播光子的收集。
