University of Manitoba, Department of Electrical and Computer Engineering, 75A Chancellor's Circle, Winnipeg, Manitoba R3T 5V6, Canada.
North Dakota State University, Department of Electrical and Computer Engineering, 1411 Centennial Boulevard, Fargo, North Dakota 58108-6050.
J Biomed Opt. 2014 Apr;19(4):046001. doi: 10.1117/1.JBO.19.4.046001.
We developed a Monte Carlo-based simulator of optical coherence tomography (OCT) imaging for turbid media with arbitrary spatial distributions. This simulator allows computation of both Class I diffusive reflectance due to ballistic and quasiballistic scattered photons and Class II diffusive reflectance due to multiple scattered photons. It was implemented using a tetrahedron-based mesh and importance sampling to significantly reduce computational time. Our simulation results were verified by comparing them with results from two previously validated OCT simulators for multilayered media. We present simulation results for OCT imaging of a sphere inside a background slab, which would not have been possible with earlier simulators. We also discuss three important aspects of our simulator: (1) resolution, (2) accuracy, and (3) computation time. Our simulator could be used to study important OCT phenomena and to design OCT systems with improved performance.
我们开发了一种基于蒙特卡罗方法的用于混浊介质的光学相干层析成像（OCT）模拟器，该模拟器具有任意空间分布。该模拟器可以计算由于弹道和拟弹道散射光子引起的 I 类漫反射率，以及由于多次散射光子引起的 II 类漫反射率。它使用基于四面体的网格和重要性抽样来显著减少计算时间。我们的模拟结果通过与之前针对多层介质的两个经过验证的 OCT 模拟器的结果进行比较来验证。我们给出了在背景平板内成像球体的 OCT 模拟结果，这在以前的模拟器中是不可能的。我们还讨论了我们的模拟器的三个重要方面：（1）分辨率，（2）准确性，和（3）计算时间。我们的模拟器可用于研究重要的 OCT 现象，并设计具有改进性能的 OCT 系统。
