Tsukanov V V, Smirnova O V, Kasparov E V, Sinyakov A A, Vasyutin A V, Tonkikh Yu L
Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science (FRC KSC SB RAS) separate division "Scientific Research Institute of medical problems of the North" (SRI MPN), Krasnoyarsk, Russia.
Ter Arkh. 2018 Feb 15;90(2):24-27. doi: 10.26442/terarkh201890224-27.
To study changes in the indices of prooxidant and antioxidant systems in plasma in men with atrophic gastritis and gastric cancer.
The study included 60 healthy men, 42 patients with atrophic gastritis and 50 men, nicardipine patients with gastric cancer stage II according to TNM. All patients underwent serological diagnosis of diffuse atrophic gastritis (definition of pepsinogens and gas- trin-17) and Helicobacter pylori infection. The diagnosis of "atrophic gastritis" was verified by morphological examination of biopsy speci- mens obtained during fibroesophagogastroduodenoscopy. Diagnosis of gastric cancer was carried out in the Krasnoyarsk regional oncologic dispensary on the basis of a comprehensive instrumental and morphological examination. All patients spectrophotometric methods in plasma was determined the content of diene conjugates (DC), malonic dialdehyde (MDA), glutathione-S-transferase (GST), glutathione peroxidase (GPO), superoxide dismutase (SOD) and catalase.
The concentration of SOD, GST, GPO and catalase had no significant differences in patients with atrophic gastritis and gastric cancer and prevailed in comparison with healthy persons. Patients with cancer of the stomach content in the blood plasma DK 2.7 times and MDA at 35.2 times higher than healthy individuals, indicating severe oxidative stress in patients with cancer. In patients with atrophic gastritis was ob- served similar but less pronounced pattern.
The results indicate the presence of oxidative stress in men with atrophic gastritis and gastric cancer.
研究萎缩性胃炎和胃癌男性患者血浆中促氧化和抗氧化系统指标的变化。
该研究纳入60名健康男性、42名萎缩性胃炎患者和50名根据TNM分期为II期胃癌的男性患者。所有患者均接受了弥漫性萎缩性胃炎的血清学诊断（胃蛋白酶原和胃泌素-17的测定）以及幽门螺杆菌感染检测。“萎缩性胃炎”的诊断通过纤维食管胃十二指肠镜检查期间获取的活检标本的形态学检查得以证实。胃癌的诊断在克拉斯诺亚尔斯克地区肿瘤防治所基于全面的仪器检查和形态学检查进行。所有患者采用分光光度法测定血浆中双烯共轭物（DC）、丙二醛（MDA）、谷胱甘肽-S-转移酶（GST）、谷胱甘肽过氧化物酶（GPO）、超氧化物歧化酶（SOD）和过氧化氢酶的含量。
萎缩性胃炎和胃癌患者中SOD、GST、GPO和过氧化氢酶的浓度与健康人相比无显著差异且含量较高。胃癌患者血浆中DK含量比健康个体高2.7倍，MDA含量高35.2倍，表明癌症患者存在严重的氧化应激。萎缩性胃炎患者中观察到类似但不太明显的模式。
结果表明萎缩性胃炎和胃癌男性患者存在氧化应激。
