Centro de Investigación del Cáncer, CSIC-University of Salamanca, Salamanca, Spain.
Instituto de Biología Molecular y Celular del Cáncer, CSIC-University of Salamanca, Salamanca, Spain.
J Endocrinol. 2019 Mar 1;240(3):483-496. doi: 10.1530/JOE-18-0623.
Multiple crosstalk between peripheral organs and the nervous system are required to maintain physiological and metabolic homeostasis. Using Vav3-deficient mice as a model for chronic sympathoexcitation-associated disorders, we report here that afferent fibers of the hepatic branch of the vagus nerve are needed for the development of the peripheral sympathoexcitation, tachycardia, tachypnea, insulin resistance, liver steatosis and adipose tissue thermogenesis present in those mice. This neuronal pathway contributes to proper activity of the rostral ventrolateral medulla, a sympathoregulatory brainstem center hyperactive in Vav3-/- mice. Vagal afferent inputs are also required for the development of additional pathophysiological conditions associated with deregulated rostral ventrolateral medulla activity. By contrast, they are dispensable for other peripheral sympathoexcitation-associated disorders sparing metabolic alterations in liver.
外周器官与神经系统之间的多种串扰对于维持生理和代谢稳态是必需的。在这里，我们使用 Vav3 缺陷型小鼠作为慢性交感兴奋相关疾病的模型，报告迷走神经肝支的传入纤维对于外周交感兴奋、心动过速、呼吸急促、胰岛素抵抗、肝脏脂肪变性和脂肪组织产热的发展是必需的。这条神经元通路有助于正确发挥延髓头端腹外侧区的作用，而延髓头端腹外侧区在 Vav3-/- 小鼠中过度活跃。迷走神经传入输入对于与调节不良的延髓头端腹外侧区活动相关的其他病理生理状况的发展也是必需的。相比之下，它们对于其他外周交感兴奋相关疾病是可有可无的，不会导致肝脏代谢改变。
