Department of Behavioral Science, Ariel University, Science Park, Ariel, Israel.
Research Unit, Geha Mental Health Center, Petah Tiqva, Israel.
Clin Pharmacol Ther. 2019 May;105(5):1139-1147. doi: 10.1002/cpt.1381. Epub 2019 Mar 12.
Cannabis is the most popular illicit drug in the Western world. Repeated cannabis use has been associated with short- and long-term side effects, including respiratory and cardiovascular disorders, cognitive alterations, psychosis, schizophrenia, and mood disorders. However, casual relations between cannabis use and these adverse effects are missing. On the other hand, recent research proposed promising therapeutic potential of cannabinoid-based drugs for a wide range of medical conditions, including neurological and psychiatric disorders. The current article presents a contemporary review on the adverse effects, safety, and the therapeutic potential of cannabis and cannabinoid-based drugs. Given the growing popularity in the use of cannabinoid-based drugs for both recreational and medical purposes and their potential harmful effects, there is a need for further investigation in this field.
大麻是西方世界最流行的非法药物。反复使用大麻会导致短期和长期的副作用,包括呼吸道和心血管疾病、认知改变、精神病、精神分裂症和情绪障碍。然而,大麻使用与这些不良反应之间的偶然关系尚未确定。另一方面,最近的研究提出了基于大麻素的药物在广泛的医疗条件下的有前途的治疗潜力,包括神经和精神疾病。本文对大麻和基于大麻素的药物的不良反应、安全性和治疗潜力进行了当代综述。鉴于大麻素类药物在娱乐和医疗用途方面的使用日益普及及其潜在的有害影响,有必要在这一领域进行进一步的研究。