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大麻素:有好有坏。

Cannabinoids: for better and for worse
.

机构信息

University Hospital Cochin, site Tarnier, Paris, France; Faculty of Medicine Paris Descartes (University of Paris); INSERM U1266, Institute of Psychiatry and Neuroscience, Paris, France, ORCID : 0000-0002-0204-5435.

Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Berlin, Germany.

出版信息

Dialogues Clin Neurosci. 2020 Sep;22(3):201-204. doi: 10.31887/DCNS.2020.22.3/fthibaut.

DOI:10.31887/DCNS.2020.22.3/fthibaut
PMID:33162763
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7605019/
Abstract

The use of cannabis as a drug has undergone a remarkable change of direction: considered as a symbol of countercultures in past decades, it is presently being hailed as a cure for any number of diseases and conditions. Thus, despite concerns about the safety of cannabis and cannabinoids, quite a few drugs that contain cannabinoids have recently been approved by several drug agencies, and the medicinal and recreational use of cannabis has been legalized in various countries and states. The promise of cannabinoids for therapeutic use, as well as potentially detrimental health risks and regulatory issues, will need to be carefully weighed.
.

摘要

大麻作为一种毒品的使用方向发生了显著变化

在过去几十年中,它曾被视为反文化的象征,但现在却被誉为可以治疗多种疾病和病症的良药。因此,尽管人们对大麻和大麻素的安全性存在担忧,但最近还是有几种含有大麻素的药物获得了多个药物监管机构的批准,而且大麻在一些国家和州也实现了医用和娱乐用合法化。因此,需要仔细权衡大麻素在治疗方面的应用前景以及其潜在的有害健康风险和监管问题。

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本文引用的文献

1
Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity.在一个具有高花生四烯酸乙醇胺浓度和疼痛不敏感的患者中发现的 FAAH 假基因中的微缺失。
Br J Anaesth. 2019 Aug;123(2):e249-e253. doi: 10.1016/j.bja.2019.02.019. Epub 2019 Mar 28.
2
Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System.大麻素受体和内源性大麻素系统:中枢神经系统中的信号传递和功能。
Int J Mol Sci. 2018 Mar 13;19(3):833. doi: 10.3390/ijms19030833.
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The direct actions of cannabidiol and 2-arachidonoyl glycerol at GABA receptors.大麻二酚和2-花生四烯酸甘油酯对γ-氨基丁酸(GABA)受体的直接作用。
Pharmacol Res. 2017 May;119:358-370. doi: 10.1016/j.phrs.2017.02.022. Epub 2017 Feb 27.
4
Changes in Cannabis Potency Over the Last 2 Decades (1995-2014): Analysis of Current Data in the United States.过去20年(1995 - 2014年)大麻效力的变化:美国当前数据分析
Biol Psychiatry. 2016 Apr 1;79(7):613-9. doi: 10.1016/j.biopsych.2016.01.004. Epub 2016 Jan 19.
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Effects of intra-prelimbic prefrontal cortex injection of cannabidiol on anxiety-like behavior: involvement of 5HT1A receptors and previous stressful experience.前边缘前扣带回皮质注射大麻二酚对焦虑样行为的影响:5-羟色胺1A受体的参与及既往应激经历
Eur Neuropsychopharmacol. 2014 Mar;24(3):410-9. doi: 10.1016/j.euroneuro.2013.10.012. Epub 2013 Oct 31.
6
Inhibitors of the endocannabinoid-degrading enzymes, or how to increase endocannabinoid's activity by preventing their hydrolysis.内源性大麻素降解酶抑制剂,或如何通过阻止其水解来提高内源性大麻素的活性。
Recent Pat CNS Drug Discov. 2012 Apr 1;7(1):49-70. doi: 10.2174/157488912798842223.
7
Probability and predictors of transition from first use to dependence on nicotine, alcohol, cannabis, and cocaine: results of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC).首次使用尼古丁、酒精、大麻和可卡因到依赖的可能性和预测因素:国家酒精流行病学调查及相关条件(NESARC)的结果。
Drug Alcohol Depend. 2011 May 1;115(1-2):120-30. doi: 10.1016/j.drugalcdep.2010.11.004. Epub 2010 Dec 8.
8
Endocannabinoids as regulators of transient receptor potential (TRP) channels: A further opportunity to develop new endocannabinoid-based therapeutic drugs.内源性大麻素作为瞬时受体电位 (TRP) 通道的调节剂:开发新型内源性大麻素类治疗药物的又一机会。
Curr Med Chem. 2010;17(14):1430-49. doi: 10.2174/092986710790980078.
9
Specific attentional dysfunction in adults following early start of cannabis use.早期开始使用大麻的成年人存在特定的注意力功能障碍。
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Molecular characterization of a peripheral receptor for cannabinoids.大麻素外周受体的分子特征
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