National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, and Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing 102206, People's Republic of China.
Virology. 2019 Mar;529:135-143. doi: 10.1016/j.virol.2019.01.002. Epub 2019 Jan 3.
H9N2 avian influenza viruses (AIVs) have become panzootic and caused sporadic human cases since 1998. Based on the poultry-related environmental surveillance data in mainland China from 2013 to 2016, a total of 68 representative environment isolates were selected and further investigated systematically. Phylogenetic analysis indicated that Y280-like H9N2 viruses have been predominant during 2013-2016 and acquired multiple specific amino acid substitutions that might favor viral transmission from avian to mammalians. Additionally, the viruses have undergone dramatic evolution and reassortment, resulting in an increased genetic diversity or acting as the gene contributors to new avian viruses. Receptor-binding tests indicated that most of the H9N2 isolates bound to human-type receptor, making them easily cross the species barrier and infect human efficiently. Our results suggested that the H9N2 AIVs prevalent in poultry may pose severe public health threat.
自 1998 年以来，H9N2 禽流感病毒（AIVs）已经流行，并导致了散发性人类病例。基于 2013 年至 2016 年中国大陆与家禽相关的环境监测数据，选择了总共 68 个具有代表性的环境分离株，并对其进行了系统的进一步调查。系统进化分析表明，Y280 样 H9N2 病毒在 2013-2016 年期间一直占主导地位，并获得了多个可能有利于病毒从禽类传播到哺乳动物的特定氨基酸取代。此外，这些病毒经历了剧烈的进化和重配，导致遗传多样性增加或成为新的禽病毒的基因贡献者。受体结合试验表明，大多数 H9N2 分离株与人型受体结合，使它们容易越过物种屏障并有效地感染人类。我们的研究结果表明，在禽类中流行的 H9N2 AIVs 可能对公共卫生构成严重威胁。
