饮食失调的认知神经科学
Cognitive Neuroscience of Eating Disorders.
作者信息
Steinglass Joanna E, Berner Laura A, Attia Evelyn
机构信息
Department of Psychiatry, New York State Psychiatric Institute, Columbia University Irving Medical Center, 1051 Riverside Drive, Unit 98, New York, NY 10032, USA.
Department of Psychiatry, University of California, San Diego, Eating Disorders Center for Treatment and Research, 4510 Executive Drive, Suite 330, San Diego, CA 92121, USA.
出版信息
Psychiatr Clin North Am. 2019 Mar;42(1):75-91. doi: 10.1016/j.psc.2018.10.008. Epub 2018 Dec 3.
Abstract
Anorexia nervosa and bulimia nervosa are characterized by severely restricted intake, binge eating, and compensatory behaviors like self-induced vomiting. The neurobiological underpinnings of these maladaptive behaviors are poorly understood, but the application of cognitive neuroscience and neuroimaging to eating disorders has begun to elucidate their pathophysiology. Specifically, this review focuses on 3 areas that suggest paths forward: reward, cognitive and behavioral control, and decision making. Understanding the brain-based mechanisms that promote and maintain these often chronic symptoms could guide the development of new and more effective treatments.
摘要
神经性厌食症和神经性贪食症的特征是摄入严重受限、暴饮暴食以及诸如自我催吐等代偿行为。这些适应不良行为的神经生物学基础尚不清楚，但认知神经科学和神经影像学在饮食失调中的应用已开始阐明其病理生理学。具体而言，本综述聚焦于三个领域，这些领域为未来指明了方向：奖赏、认知与行为控制以及决策。了解促进和维持这些往往具有慢性特征症状的基于大脑的机制，可为开发新的、更有效的治疗方法提供指导。
相似文献
1
Cognitive Neuroscience of Eating Disorders.饮食失调的认知神经科学
Psychiatr Clin North Am. 2019 Mar;42(1):75-91. doi: 10.1016/j.psc.2018.10.008. Epub 2018 Dec 3.
2
Altered structural and effective connectivity in anorexia and bulimia nervosa in circuits that regulate energy and reward homeostasis.在调节能量和奖赏稳态的神经回路中，神经性厌食症和神经性贪食症患者的结构连接性和功能连接性发生改变。
Transl Psychiatry. 2016 Nov 1;6(11):e932. doi: 10.1038/tp.2016.199.
3
Recent advances in neuroimaging to model eating disorder neurobiology.神经影像学在进食障碍神经生物学模型中的最新进展。
Curr Psychiatry Rep. 2015 Apr;17(4):559. doi: 10.1007/s11920-015-0559-z.
4
Alterations in brain structures related to taste reward circuitry in ill and recovered anorexia nervosa and in bulimia nervosa.厌食症和贪食症患者在患病和康复期间，与味觉奖励回路相关的大脑结构发生改变。
Am J Psychiatry. 2013 Oct;170(10):1152-60. doi: 10.1176/appi.ajp.2013.12101294.
5
Dysregulation of brain reward systems in eating disorders: neurochemical information from animal models of binge eating, bulimia nervosa, and anorexia nervosa.进食障碍中大脑奖励系统的失调：暴食、神经性贪食症和神经性厌食症动物模型的神经化学信息。
Neuropharmacology. 2012 Jul;63(1):87-96. doi: 10.1016/j.neuropharm.2011.11.010. Epub 2011 Nov 27.
6
Does a shared neurobiology for foods and drugs of abuse contribute to extremes of food ingestion in anorexia and bulimia nervosa?食物和药物滥用的共同神经生物学是否导致神经性厌食症和神经性贪食症中极端的食物摄入？
Biol Psychiatry. 2013 May 1;73(9):836-42. doi: 10.1016/j.biopsych.2013.01.002. Epub 2013 Feb 4.
7
Neuroendocrinology of reward in anorexia nervosa and bulimia nervosa: Beyond leptin and ghrelin.神经性厌食症和神经性贪食症的奖赏神经内分泌学：超越瘦素和胃饥饿素。
Mol Cell Endocrinol. 2019 Nov 1;497:110320. doi: 10.1016/j.mce.2018.10.018. Epub 2018 Nov 2.
8
Perplexities and provocations of eating disorders.饮食失调的困惑与诱因
J Child Psychol Psychiatry. 2009 Jan;50(1-2):163-9. doi: 10.1111/j.1469-7610.2008.01983.x.
9
Altered insula response to sweet taste processing after recovery from anorexia and bulimia nervosa.神经性厌食和贪食症康复后，岛叶对甜味处理的反应发生改变。
Am J Psychiatry. 2013 Oct;170(10):1143-51. doi: 10.1176/appi.ajp.2013.11111745.
10
Personality Variables and Eating Pathology.人格变量与饮食病理学。
Psychiatr Clin North Am. 2019 Mar;42(1):105-119. doi: 10.1016/j.psc.2018.10.012. Epub 2018 Dec 17.
引用本文的文献
1
Computational Perspectives on Cognition in Anorexia Nervosa: A Systematic Review.神经性厌食症认知的计算视角：一项系统综述
Comput Psychiatr. 2025 Apr 7;9(1):100-121. doi: 10.5334/cpsy.128. eCollection 2025.
2
Multimodal quantitative magnetic resonance imaging alterations of the basal ganglia circuit underlie the severity of bulimia nervosa.神经性贪食症的严重程度与基底神经节回路的多模态定量磁共振成像改变有关。
Int J Clin Health Psychol. 2025 Jan-Mar;25(1):100557. doi: 10.1016/j.ijchp.2025.100557. Epub 2025 Mar 13.
3
Willing to wait: Anorexia nervosa symptomatology is associated with higher future orientation and reduced intertemporal discounting.愿意等待：神经性厌食症症状与更高的未来导向和更低的跨期贴现相关。
Sci Rep. 2025 Feb 6;15(1):4508. doi: 10.1038/s41598-024-80597-7.
4
The current clinical approach to feeding and eating disorders aimed to increase personalization of management.当前针对进食和饮食障碍的临床方法旨在提高管理的个性化程度。
World Psychiatry. 2025 Feb;24(1):4-31. doi: 10.1002/wps.21263.
5
Exploring the neurobiological correlates of psilocybin-assisted psychotherapy in eating disorders: a review of potential methodologies and implications for the psychedelic study design.探索裸盖菇素辅助心理治疗饮食失调的神经生物学相关性：潜在方法综述及其对迷幻剂研究设计的启示
J Eat Disord. 2024 Dec 27;12(1):214. doi: 10.1186/s40337-024-01185-8.
6
Neuroimaging studies of resting-state functional magnetic resonance imaging in eating disorders.进食障碍的静息态功能磁共振神经影像学研究。
BMC Med Imaging. 2024 Oct 7;24(1):265. doi: 10.1186/s12880-024-01432-z.
7
Therapeutic ketogenic diet as treatment for anorexia nervosa.治疗性生酮饮食作为神经性厌食症的治疗方法。
Front Nutr. 2024 Sep 4;11:1392135. doi: 10.3389/fnut.2024.1392135. eCollection 2024.
8
The Contribution of the Brain-Gut Axis to the Human Reward System.脑-肠轴对人类奖赏系统的作用。
Biomedicines. 2024 Aug 15;12(8):1861. doi: 10.3390/biomedicines12081861.
9
Waiting for it: Anorexia Risk, Future Orientation, and Intertemporal Discounting.拭目以待：厌食风险、未来导向与跨期贴现
Res Sq. 2024 Mar 27:rs.3.rs-4002723. doi: 10.21203/rs.3.rs-4002723/v1.
10
Neuromodulation of Eating Disorders: A Review of Underlying Neural Network Activity and Neuromodulatory Treatments.饮食失调的神经调节：潜在神经网络活动及神经调节治疗综述
Brain Sci. 2024 Feb 22;14(3):200. doi: 10.3390/brainsci14030200.
本文引用的文献
1
What can food-image tasks teach us about anorexia nervosa? A systematic review.食物图像任务能让我们了解神经性厌食症的哪些方面？一项系统综述。
J Eat Disord. 2018 Nov 1;6:31. doi: 10.1186/s40337-018-0217-z. eCollection 2018.
2
A systematic review of reviews of neurocognitive functioning in eating disorders: The state-of-the-literature and future directions.进食障碍神经认知功能的系统评价综述：文献现状与未来方向。
Int J Eat Disord. 2018 Aug;51(8):798-821. doi: 10.1002/eat.22929. Epub 2018 Aug 13.
3
Can delay discounting deliver on the promise of RDoC?延迟折扣能否兑现 RDoC 的承诺？
Psychol Med. 2019 Jan;49(2):190-199. doi: 10.1017/S0033291718001770. Epub 2018 Aug 2.
4
Association of Brain Reward Learning Response With Harm Avoidance, Weight Gain, and Hypothalamic Effective Connectivity in Adolescent Anorexia Nervosa.青少年神经性厌食症中大脑奖励学习反应与回避伤害、体重增加和下丘脑有效连接的关联。
JAMA Psychiatry. 2018 Oct 1;75(10):1071-1080. doi: 10.1001/jamapsychiatry.2018.2151.
5
Altered cortical thickness and attentional deficits in adolescent girls and women with bulimia nervosa.神经性贪食症青少年女性患者的皮质厚度改变和注意力缺陷。
J Psychiatry Neurosci. 2018 May;43(3):151-160. doi: 10.1503/jpn.170070.
6
Abnormal fronto-striatal activation as a marker of threshold and subthreshold Bulimia Nervosa.异常的额-纹状体激活可作为阈下和边缘性贪食症的标志物。
Hum Brain Mapp. 2018 Apr;39(4):1796-1804. doi: 10.1002/hbm.23955. Epub 2018 Jan 10.
7
Delay Discounting of Reward and Impulsivity in Eating Disorders: From Anorexia Nervosa to Binge Eating Disorder.饮食失调中奖励的延迟折扣与冲动性：从神经性厌食症到暴饮暴食症
Eur Eat Disord Rev. 2017 Nov;25(6):601-606. doi: 10.1002/erv.2543.
8
Altered intrinsic functional brain architecture in female patients with bulimia nervosa.神经性贪食症女性患者大脑固有功能连接的改变。
J Psychiatry Neurosci. 2017 Nov;42(6):414-423. doi: 10.1503/jpn.160183.
9
Reduced Inferior and Orbital Frontal Thickness in Adolescent Bulimia Nervosa Persists Over Two-Year Follow-Up.青少年神经性贪食症患者下眶额和额眶部厚度减少，在两年随访中持续存在。
J Am Acad Child Adolesc Psychiatry. 2017 Oct;56(10):866-874.e7. doi: 10.1016/j.jaac.2017.08.008. Epub 2017 Aug 19.
10
Response in taste circuitry is not modulated by hunger and satiety in women remitted from bulimia nervosa.神经性贪食症缓解期女性的味觉回路反应不受饥饿和饱腹感的调节。
J Abnorm Psychol. 2017 Jul;126(5):519-530. doi: 10.1037/abn0000218.
Zotero 插件