人催乳素分泌型垂体腺瘤及非肿瘤性垂体催乳素细胞中催乳素（PRL）的免疫电子显微镜观察

Immunoelectron microscopic observation of prolactin (PRL) in human PRL secreting pituitary adenomas and non-neoplastic pituitary PRL cells.

作者信息

Osamura R Y

机构信息

Department of Pathology, Tokai University School of Medicine, Japan.

出版信息

Pathol Res Pract. 1988 Sep;183(5):584-6. doi: 10.1016/s0344-0338(88)80016-5.

DOI:10.1016/s0344-0338(88)80016-5

PMID:3070508

Abstract

Immunoelectron microscopic localization of prolactin (PRL) was studied in pituitary adenoma cells and in non-neoplastic PRL cells. The adenoma cells showed characteristic concentration of PRL in Golgi region which was ultrastructurally in Golgi saccules and in vesicular RER. In contrast, the non-neoplastic PRL cells showed lamellated RER which contained PRL. These results suggested disproportional production of PRL and its secretion in the adenoma cells.

摘要

在垂体腺瘤细胞和非肿瘤性催乳素（PRL）细胞中研究了催乳素的免疫电子显微镜定位。腺瘤细胞显示PRL在高尔基体区域有特征性聚集，在超微结构上位于高尔基体囊泡和泡状粗面内质网中。相比之下，非肿瘤性PRL细胞显示含有PRL的板层状粗面内质网。这些结果提示腺瘤细胞中PRL的产生及其分泌不均衡。