Mammosomatotropes in human pituitary adenomas as revealed by electron microscopic double gold immunostaining method.
作者信息
Beckers A, Courtoy R, Stevenaert A, Boniver J, Closset J, Frankenne F, Reznik M, Hennen G
机构信息
Endocrinologie Clinique et Expérimentale, Université de Liège, Belgique.
出版信息
Acta Endocrinol (Copenh). 1988 Aug;118(4):503-12. doi: 10.1530/acta.0.1180503.
PMID:3400404
Abstract
Hormone production was studied in situ by immunocytochemical methods in 20 pituitary adenomas. Special attention was given to 13 adenomas removed from acromegalic patients. Out of them, 6 had mild to moderate hyperprolactinemia. Immunohistochemistry revealed PRL-containing cells without any close relationship with high PRL serum level in 6 patients. Double immunogold staining revealed mammosomatotrope cells characterized by simultaneous presence of GH and PRL in the same granules in 2 patients. Since mammosomatotropes have never been demonstrated in the normal pituitary, our results probably signify gene dysregulation in pituitary cells of those acromegalic patients.
摘要
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