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CD371 cell surface expression: a unique feature of -rearranged acute lymphoblastic leukemia.CD371细胞表面表达：重排型急性淋巴细胞白血病的独特特征。
Haematologica. 2019 Aug;104(8):e352-e355. doi: 10.3324/haematol.2018.214353. Epub 2019 Jan 31.
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Frequencies and prognostic impact of RAS mutations in MLL-rearranged acute lymphoblastic leukemia in infants.婴儿中 MLL 重排的急性淋巴细胞白血病中 RAS 突变的频率和预后影响。
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deletions in childhood acute lymphoblastic leukemia with rearrangements are mostly polyclonal, prognostically relevant and their detection rate strongly depends on screening method sensitivity.在伴有重排的儿童急性淋巴细胞白血病中，缺失大多是多克隆的，与预后相关，其检出率强烈依赖于筛选方法的灵敏度。
Haematologica. 2019 Jul;104(7):1407-1416. doi: 10.3324/haematol.2018.204487. Epub 2019 Jan 10.
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Deregulation of DUX4 and ERG in acute lymphoblastic leukemia.急性淋巴细胞白血病中DUX4和ERG的失调
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Expression of miR-196b is not exclusively MLL-driven but is especially linked to activation of HOXA genes in pediatric acute lymphoblastic leukemia.miR-196b 的表达并非完全由 MLL 驱动，而是与小儿急性淋巴细胞白血病中 HOXA 基因的激活特别相关。
Haematologica. 2010 Oct;95(10):1675-82. doi: 10.3324/haematol.2010.023481. Epub 2010 May 21.
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MEF2D-rearranged acute lymphoblastic leukemia resembles Burkitt lymphoma/leukemia.MEF2D重排的急性淋巴细胞白血病类似于伯基特淋巴瘤/白血病。
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Frequent co-expression of HoxA9 and Meis1 genes in infant acute lymphoblastic leukaemia with MLL rearrangement.HoxA9和Meis1基因在伴有MLL重排的婴儿急性淋巴细胞白血病中频繁共表达。
Br J Haematol. 2002 Oct;119(1):119-21. doi: 10.1046/j.1365-2141.2002.03803.x.
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Expression of NG2 antigen in MLL-rearranged acute leukemias: how complex does it get?MLL重排急性白血病中NG2抗原的表达：其复杂性究竟如何？
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N-terminus DUX4-immunohistochemistry is a reliable methodology for the diagnosis of DUX4-fused B-lymphoblastic leukemia/lymphoma (N-terminus DUX4 IHC for DUX4-fused B-ALL).DUX4 免疫组化检测 N 端用于诊断 DUX4 融合型 B 淋巴母细胞白血病/淋巴瘤（DUX4 融合型 B-ALL 的 N 端 DUX4 免疫组化）。
Genes Chromosomes Cancer. 2022 Aug;61(8):449-458. doi: 10.1002/gcc.23033. Epub 2022 Mar 7.
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Emerging molecular subtypes and therapies in acute lymphoblastic leukemia.急性淋巴细胞白血病的新兴分子亚型和治疗方法。
Semin Diagn Pathol. 2023 May;40(3):202-215. doi: 10.1053/j.semdp.2023.04.003. Epub 2023 Apr 9.

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Leukemia. 2025 Sep 12. doi: 10.1038/s41375-025-02758-5.
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Rapid Identification of Fusion in Acute Lymphoblastic Leukemia.急性淋巴细胞白血病中融合基因的快速鉴定
EJHaem. 2025 Jul 28;6(4):e70099. doi: 10.1002/jha2.70099. eCollection 2025 Aug.
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C-type lectin-like molecule-1 as a diagnostic, prognostic, and therapeutic marker in leukemia.C型凝集素样分子-1作为白血病的诊断、预后及治疗标志物
Mol Biol Rep. 2025 May 16;52(1):464. doi: 10.1007/s11033-025-10527-x.
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Effective Utilization of a Customized Targeted Hybrid Capture RNA Sequencing in the Routine Molecular Categorization of Adolescent and Adult B-Lineage Acute Lymphoblastic Leukemia: A Real-World Experience.定制靶向杂交捕获RNA测序在青少年和成人B淋巴细胞系急性淋巴细胞白血病常规分子分类中的有效应用：一项真实世界经验
Mol Diagn Ther. 2025 May;29(3):407-418. doi: 10.1007/s40291-025-00779-5. Epub 2025 Apr 5.
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Identification of Rearrangements Using RNA-sequencing in a Patient with ALL: A Case Report.利用RNA测序在一名急性淋巴细胞白血病患者中鉴定重排：病例报告
Ann Lab Med. 2025 May 1;45(3):339-342. doi: 10.3343/alm.2024.0622. Epub 2025 Apr 3.
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RNA-sequencing: A reliable tool to unveil transcriptional landscape of paediatric B-other acute lymphoblastic leukaemia.RNA测序：揭示儿童B-其他急性淋巴细胞白血病转录图谱的可靠工具。
Br J Haematol. 2025 May;206(5):1355-1365. doi: 10.1111/bjh.20056. Epub 2025 Mar 30.
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Unveiling the potential of CLL-1: a promising target for AML therapy.揭示CLL-1的潜力：急性髓系白血病治疗的一个有前景的靶点。
Biomark Res. 2025 Feb 12;13(1):28. doi: 10.1186/s40364-025-00738-6.
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CD36 cell surface expression as a surrogate marker to identify ABL/JAK-class kinase fusions in pediatric BCP-ALL.CD36细胞表面表达作为一种替代标志物，用于鉴定儿童B细胞前体急性淋巴细胞白血病中的ABL/JAK类激酶融合。
Leukemia. 2025 Jan;39(1):64-74. doi: 10.1038/s41375-024-02421-5. Epub 2024 Oct 17.
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Risk factors in DUX4-positive childhood and adolescent B-cell acute lymphoblastic leukemia.DUX4 阳性的儿童和青少年 B 细胞急性淋巴细胞白血病的危险因素。
Blood Cancer J. 2024 Jul 22;14(1):119. doi: 10.1038/s41408-024-01099-3.
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Single-cell genomics details the maturation block in BCP-ALL and identifies therapeutic vulnerabilities in DUX4-r cases.单细胞基因组学详细描述了 BCP-ALL 中的成熟阻滞，并确定了 DUX4-r 病例中的治疗弱点。
Blood. 2024 Sep 26;144(13):1399-1411. doi: 10.1182/blood.2023021705.

本文引用的文献

1
Advances in B-cell Precursor Acute Lymphoblastic Leukemia Genomics.B 细胞前体急性淋巴细胞白血病基因组学的进展
Hemasphere. 2018 Jun 20;2(4):e53. doi: 10.1097/HS9.0000000000000053. eCollection 2018 Aug.
2
Prognostic and therapeutic role of CLEC12A in acute myeloid leukemia.CLEC12A 在急性髓系白血病中的预后和治疗作用。
Blood Rev. 2019 Mar;34:26-33. doi: 10.1016/j.blre.2018.10.003. Epub 2018 Nov 1.
3
IKZF1 Defines a New Minimal Residual Disease-Dependent Very-Poor Prognostic Profile in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia.IKZF1 在小儿 B 细胞前体急性淋巴细胞白血病中定义了一种新的与微小残留病灶相关的非常差预后的最小残留病灶依赖性预后模型。
J Clin Oncol. 2018 Apr 20;36(12):1240-1249. doi: 10.1200/JCO.2017.74.3617. Epub 2018 Mar 2.
4
Genotype-Specific Minimal Residual Disease Interpretation Improves Stratification in Pediatric Acute Lymphoblastic Leukemia.基因型特异性微小残留病解读可改善儿童急性淋巴细胞白血病的分层。
J Clin Oncol. 2018 Jan 1;36(1):34-43. doi: 10.1200/JCO.2017.74.0449. Epub 2017 Nov 13.
5
Genetic Basis of Acute Lymphoblastic Leukemia.急性淋巴细胞白血病的遗传基础
J Clin Oncol. 2017 Mar 20;35(9):975-983. doi: 10.1200/JCO.2016.70.7836. Epub 2017 Feb 13.
6
AIEOP-BFM consensus guidelines 2016 for flow cytometric immunophenotyping of Pediatric acute lymphoblastic leukemia.AIEOP-BFM 共识指南 2016 年版：儿童急性淋巴细胞白血病流式细胞免疫表型分析
Cytometry B Clin Cytom. 2018 Jan;94(1):82-93. doi: 10.1002/cyto.b.21518. Epub 2017 Feb 21.
7
Deregulation of DUX4 and ERG in acute lymphoblastic leukemia.急性淋巴细胞白血病中DUX4和ERG的失调
Nat Genet. 2016 Dec;48(12):1481-1489. doi: 10.1038/ng.3691. Epub 2016 Oct 24.
8
Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia.在小儿 B 细胞前体急性淋巴细胞白血病中鉴定 ETV6-RUNX1 样和 DUX4 重排亚型。
Nat Commun. 2016 Jun 6;7:11790. doi: 10.1038/ncomms11790.
9
Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults.青少年和年轻成人 B 细胞急性淋巴细胞白血病中的复发性 DUX4 融合。
Nat Genet. 2016 May;48(5):569-74. doi: 10.1038/ng.3535. Epub 2016 Mar 28.
10
CD2-positive B-cell precursor acute lymphoblastic leukemia with an early switch to the monocytic lineage.CD2 阳性 B 细胞前体急性淋巴细胞白血病向单核细胞系早期分化。
Leukemia. 2014 Mar;28(3):609-20. doi: 10.1038/leu.2013.354. Epub 2013 Nov 25.

CD371 cell surface expression: a unique feature of -rearranged acute lymphoblastic leukemia.

作者信息

Schinnerl Dagmar, Mejstrikova Ester, Schumich Angela, Zaliova Marketa, Fortschegger Klaus, Nebral Karin, Attarbaschi Andishe, Fiser Karel, Kauer Maximilian O, Popitsch Niko, Haslinger Sabrina, Inthal Andrea, Buldini Barbara, Basso Giuseppe, Bourquin Jean-Pierre, Gaipa Giuseppe, Brüggemann Monika, Feuerstein Tamar, Maurer-Granofszky Margarita, Panzer-Grümayer Renate, Trka Jan, Mann Georg, Haas Oskar A, Hrusak Ondrej, Dworzak Michael N, Strehl Sabine

机构信息

CCRI, Children's Cancer Research Institute, St. Anna Kinderkrebsforschung, Vienna, Austria.

CLIP - Childhood Leukemia Investigation Prague, Prague, Czech Republic.

出版信息

Haematologica. 2019 Aug;104(8):e352-e355. doi: 10.3324/haematol.2018.214353. Epub 2019 Jan 31.

DOI:10.3324/haematol.2018.214353
PMID:30705095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6669149/
Abstract
摘要