Departments of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA.
Departments of Biostatistics, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA.
Sci Rep. 2019 Jan 31;9(1):1074. doi: 10.1038/s41598-019-38550-6.
Chromosome changes are one of the hallmarks of human malignancies. Chromosomal rearrangement is frequent in human cancers. One of the consequences of chromosomal rearrangement is gene fusions in the cancer genome. We have previously identified a panel of fusion genes in aggressive prostate cancers. In this study, we showed that 6 of these fusion genes are present in 7 different types of human malignancies with variable frequencies. Among them, the CCNH-C5orf30 and TRMT11-GRIK2 gene fusions were found in breast cancer, colon cancer, non-small cell lung cancer, esophageal adenocarcinoma, glioblastoma multiforme, ovarian cancer and liver cancer, with frequencies ranging from 12.9% to 85%. In contrast, four other gene fusions (mTOR-TP53BP1, TMEM135-CCDC67, KDM4-AC011523.2 and LRRC59-FLJ60017) are less frequent. Both TRMT11-GRIK2 and CCNH-C5orf30 are also frequently present in lymph node metastatic cancer samples from the breast, colon and ovary. Thus, detecting these fusion transcripts may have significant biological and clinical implications in cancer patient management.
染色体变化是人类恶性肿瘤的特征之一。染色体重排在人类癌症中很常见。染色体重排的后果之一是癌症基因组中的基因融合。我们之前已经在侵袭性前列腺癌中鉴定了一组融合基因。在这项研究中，我们表明，这 6 个融合基因存在于不同类型的人类恶性肿瘤中，频率不同。其中，CCNH-C5orf30 和 TRMT11-GRIK2 基因融合存在于乳腺癌、结肠癌、非小细胞肺癌、食管腺癌、胶质母细胞瘤、卵巢癌和肝癌中，频率从 12.9%到 85%不等。相比之下，其他四个基因融合（mTOR-TP53BP1、TMEM135-CCDC67、KDM4-AC011523.2 和 LRRC59-FLJ60017）则较少见。TRMT11-GRIK2 和 CCNH-C5orf30 也经常存在于乳腺癌、结肠癌和卵巢的淋巴结转移癌样本中。因此，检测这些融合转录本可能对癌症患者的管理具有重要的生物学和临床意义。
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