Wang Yiqin, Zhou Rong, Wang Jianliu
Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China.
Aging Dis. 2019 Feb 1;10(1):190-196. doi: 10.14336/AD.2018.0224. eCollection 2019 Feb.
Thyroid dysfunction is involved in several types of carcinoma. Hypothyroidism is one of the most common medical morbidities among patients with endometrial cancer; however, the related mechanism is unclear. Among the risk factors related to endometrial cancer, hypothyroidism interacts with metabolic syndrome, polycystic ovarian syndrome and infertility or directly acts on the endometrium itself, which may influence the development and progression of endometrial cancer. We summarize recent studies on the relationship between hypothyroidism and endometrial cancer and its risk factors to provide references for basic research as well as for clinical treatment and prognostic evaluation.
甲状腺功能障碍与多种类型的癌症有关。甲状腺功能减退是子宫内膜癌患者中最常见的医学病症之一；然而，其相关机制尚不清楚。在与子宫内膜癌相关的危险因素中，甲状腺功能减退与代谢综合征、多囊卵巢综合征和不孕症相互作用，或直接作用于子宫内膜本身，这可能会影响子宫内膜癌的发生和发展。我们总结了甲状腺功能减退与子宫内膜癌及其危险因素之间关系的最新研究，为基础研究以及临床治疗和预后评估提供参考。
