甲状腺功能减退与子宫内膜癌之间的关系。
Relationship between Hypothyroidism and Endometrial Cancer.
作者信息
Wang Yiqin, Zhou Rong, Wang Jianliu
机构信息
Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China.
出版信息
Aging Dis. 2019 Feb 1;10(1):190-196. doi: 10.14336/AD.2018.0224. eCollection 2019 Feb.
Abstract
Thyroid dysfunction is involved in several types of carcinoma. Hypothyroidism is one of the most common medical morbidities among patients with endometrial cancer; however, the related mechanism is unclear. Among the risk factors related to endometrial cancer, hypothyroidism interacts with metabolic syndrome, polycystic ovarian syndrome and infertility or directly acts on the endometrium itself, which may influence the development and progression of endometrial cancer. We summarize recent studies on the relationship between hypothyroidism and endometrial cancer and its risk factors to provide references for basic research as well as for clinical treatment and prognostic evaluation.
摘要
甲状腺功能障碍与多种类型的癌症有关。甲状腺功能减退是子宫内膜癌患者中最常见的医学病症之一；然而，其相关机制尚不清楚。在与子宫内膜癌相关的危险因素中，甲状腺功能减退与代谢综合征、多囊卵巢综合征和不孕症相互作用，或直接作用于子宫内膜本身，这可能会影响子宫内膜癌的发生和发展。我们总结了甲状腺功能减退与子宫内膜癌及其危险因素之间关系的最新研究，为基础研究以及临床治疗和预后评估提供参考。
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本文引用的文献
1
[THE CLINICAL APPROACH TO DIAGNOSIS AND TREATMENT OF HYPOTHYROIDISM].[甲状腺功能减退症的诊断与治疗临床方法]
Harefuah. 2017 May;156(5):322-325.
2
Distribution of thyroid hormone and thyrotropin receptors in reproductive tissues of adult female rabbits.成年雌性兔生殖组织中甲状腺激素和促甲状腺激素受体的分布
Endocr Res. 2017 Feb;42(1):59-70. doi: 10.1080/07435800.2016.1182185. Epub 2016 Jun 7.
3
Normal "high" thyroid stimulating hormone (TSH) levels and pregnancy rates in patients undergoing IVF with donor eggs.接受供卵体外受精患者的正常“高”促甲状腺激素（TSH）水平与妊娠率
Clin Exp Obstet Gynecol. 2014;41(5):517-20.
4
Leptin Inhibits the Apoptosis of Endometrial Carcinoma Cells Through Activation of the Nuclear Factor κB-inducing Kinase/IκB Kinase Pathway.瘦素通过激活核因子κB诱导激酶/IκB激酶途径抑制子宫内膜癌细胞凋亡。
Int J Gynecol Cancer. 2015 Jun;25(5):770-8. doi: 10.1097/IGC.0000000000000440.
5
Long-term Clinical Outcomes After Resectoscopic Endometrial Ablation of Nonatypical Endometrial Hyperplasia in Women With Abnormal Uterine Bleeding.子宫异常出血女性非典型子宫内膜增生经宫腔镜子宫内膜切除术的长期临床结局
J Minim Invasive Gynecol. 2015 May-Jun;22(4):704. doi: 10.1016/j.jmig.2015.02.017. Epub 2015 Mar 4.
6
The prevalence of the metabolic syndrome increases through the quartiles of thyroid stimulating hormone in a population-based sample of euthyroid subjects.在一组甲状腺功能正常受试者的人群样本中，代谢综合征的患病率随促甲状腺激素四分位数的增加而升高。
Arq Bras Endocrinol Metabol. 2014 Dec;58(9):926-32. doi: 10.1590/0004-2730000003538.
7
Increased TSH in obesity: Evidence for a BMI-independent association with leptin.肥胖症患者中 TSH 增加：瘦素与之呈 BMI 独立相关的证据。
Diabetes Metab. 2015 Jun;41(3):248-51. doi: 10.1016/j.diabet.2014.11.009. Epub 2014 Dec 22.
8
Mechanisms in endocrinology: thyroid and polycystic ovary syndrome.内分泌学机制：甲状腺与多囊卵巢综合征
Eur J Endocrinol. 2015 Jan;172(1):R9-21. doi: 10.1530/EJE-14-0295.
9
High leptin level is an independent risk factor of endometrial cancer: a meta-analysis.高瘦素水平是子宫内膜癌的独立危险因素：一项荟萃分析。
Cell Physiol Biochem. 2014;34(5):1477-84. doi: 10.1159/000366352. Epub 2014 Oct 8.
10
Medical morbidities in endometrial cancer patients.子宫内膜癌患者的医学合并症
Int J Gynecol Cancer. 2014 Nov;24(9):1623-7. doi: 10.1097/IGC.0000000000000291.
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