Yu Qi, Chen Ya-Lian, Zhou Shui-Hong, Chen Zhe, Bao Yang-Yang, Yang Han-Jin, Yao Hong-Tian, Ruan Ling-Xiang
Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.
World J Clin Cases. 2019 Jan 26;7(2):242-252. doi: 10.12998/wjcc.v7.i2.242.
Collision carcinoma is rare in clinical practice, especially in the head and neck region. In this paper, we report a case of squamous cell carcinoma (SCC) and neuroendocrine carcinoma (NEC) colliding in the larynx and review 12 cases of collision carcinoma in the head and neck to further understand collision carcinoma, including its definition, diagnosis, and treatment.
A 61-year-old man presented with a 1-year history of hoarseness. Contrast-enhanced magnetic resonance imaging of the larynx revealed that the right vocal cord had a nodule-like thickening with obvious enhancement. Laryngoscopy revealed a neoplasm on the right vocal cord, and a malignant tumor was initially considered. A frozen section of right vocal cord was performed under general anesthesia. The pathological result showed a malignant tumor in the right vocal cord. The tumor was excised with a CO laser (V type). Routine postoperative pathology showed moderately differentiated SCC with small cell NEC in the right vocal cord. No metastatic lymph nodes or distant metastases were found on postoperative positron emission tomography/computed tomography. Because of the coexistence of SCC and NEC, the patient received adjuvant chemotherapy and radiotherapy. The patient was followed for 8 mo, and no recurrence or distant metastasis was found.
The treatment of collision carcinoma in the head and neck region is uncertain due to the small number of cases.
碰撞癌在临床实践中较为罕见，尤其是在头颈部区域。在本文中，我们报告一例喉鳞状细胞癌（SCC）与神经内分泌癌（NEC）碰撞的病例，并回顾12例头颈部碰撞癌病例，以进一步了解碰撞癌，包括其定义、诊断和治疗。
一名61岁男性，有1年声音嘶哑病史。喉部增强磁共振成像显示右侧声带结节样增厚，强化明显。喉镜检查发现右侧声带肿物，初步考虑为恶性肿瘤。在全身麻醉下对右侧声带进行冰冻切片检查。病理结果显示右侧声带为恶性肿瘤。采用CO2激光（V型）切除肿瘤。术后常规病理显示右侧声带为中分化鳞状细胞癌合并小细胞神经内分泌癌。术后正电子发射断层扫描/计算机断层扫描未发现转移淋巴结或远处转移。由于同时存在鳞状细胞癌和神经内分泌癌，患者接受了辅助化疗和放疗。对患者进行了8个月的随访，未发现复发或远处转移。
由于头颈部碰撞癌病例数较少，其治疗方法尚不明确。
