Xu Sheng, Xu Lei, Cao Peng, Yao Shiyun, Wu Tingming, Hu Xinming, Chen Hualei, Gu Jun, Che Xianping
Department of Urology, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Department of Pathology, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Front Oncol. 2021 Jul 5;11:663119. doi: 10.3389/fonc.2021.663119. eCollection 2021.
Small cell neuroendocrine carcinoma (SCNEC) of the ureter is a rare tumour, accounting for less than 0.5% of all ureteral tumours. SCNEC tumours are highly aggressive and patients have a poor prognosis. Ureteral SCNEC colliding with other pathological types of tumours is extremely rare. In this paper, we present the case of a patient with ureteral small cell carcinoma colliding with squamous cell carcinoma and review the literature regarding the clinicopathological features, treatment and prognosis of thus tumour. To the best of our knowledge, this is the second identified case of ureteral SCNEC colliding with SCC.
A 64-year-old male patient presented with a history of 1 month of gross haematuria and 3 months of left flank pain. CT urography revealed a soft tissue mass in the upper ureter, which was slightly enhanced on contrast-enhanced CT. Nephroureterectomy was performed after the patient was diagnosed with a tumour in the left ureter. Microscopy and immunohistochemical examination confirmed the mass to be a SCNEC collision with SCC. Two months after the surgery, the patient received adjuvant chemotherapy (cisplatin/etoposide). After 14 months of follow-up, no local recurrence or distant metastasis was found.
Ureteral collision carcinoma with SCNEC predominantly occurs in Asian individuals, is difficult to diagnose preoperatively and is highly invasive. The current management of ureteral collision carcinoma is a comprehensive treatment based on surgery.
输尿管小细胞神经内分泌癌（SCNEC）是一种罕见肿瘤，占所有输尿管肿瘤的比例不到0.5%。SCNEC肿瘤具有高度侵袭性，患者预后较差。输尿管SCNEC与其他病理类型的肿瘤碰撞极为罕见。在本文中，我们报告了一例输尿管小细胞癌与鳞状细胞癌碰撞的患者病例，并回顾了有关该肿瘤临床病理特征、治疗及预后的文献。据我们所知，这是第二例已确认的输尿管SCNEC与SCC碰撞的病例。
一名64岁男性患者，有1个月肉眼血尿病史及3个月左侧腰痛病史。CT尿路造影显示输尿管上段有一软组织肿块，增强CT扫描显示其有轻度强化。在患者被诊断为左输尿管肿瘤后，实施了肾输尿管切除术。显微镜检查和免疫组化检查证实该肿块为SCNEC与SCC的碰撞。术后2个月，患者接受了辅助化疗（顺铂/依托泊苷）。经过14个月的随访，未发现局部复发或远处转移。
输尿管SCNEC碰撞癌主要发生在亚洲人群中，术前难以诊断，且具有高度侵袭性。目前输尿管碰撞癌的治疗是以手术为主的综合治疗。
