Wu Shi-Hai, Zhang Bao-Zhu, Han Ling
Department of Radiation Oncology, the Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen 518020, Guangdong Province, China.
Department of Oncology, The People's Hospital of Baoan, Shenzhen, The Affiliated Baoan Hospital of Southern Medical University, Shenzhen 518020, Guangdong Province, China.
World J Clin Cases. 2020 Jun 26;8(12):2610-2616. doi: 10.12998/wjcc.v8.i12.2610.
There are many disputes about the definition, diagnosis, therapy, and prognosis of collision tumors.
We describe a rare patient with a collision tumor consisting of neuroendocrine carcinoma (NEC) and squamous cell carcinoma (SCC) in the nasal cavity and paranasal sinus. She received operation, concurrent chemoradiotherapy, and then two cycles of palliative chemotherapy. Follow-up at 12 mo after diagnosis showed that this patient experienced a complete response with no signs of recurrence or metastasis. A literature review of previous 26 cases diagnosed with collision tumor of NEC and SCC in the head and neck was also undertaken.
It is challenging to manage collision tumors because there are two morphologically and etiologically distinct tumors. Well-designed multimodality therapy including surgery and chemoradiotherapy might lead to a long survival in these patients.
关于碰撞瘤的定义、诊断、治疗及预后存在诸多争议。
我们描述了一名罕见的鼻腔及鼻窦碰撞瘤患者，该肿瘤由神经内分泌癌（NEC）和鳞状细胞癌（SCC）组成。她接受了手术、同步放化疗，随后进行了两个周期的姑息化疗。诊断后12个月的随访显示，该患者完全缓解，无复发或转移迹象。我们还对先前26例诊断为头颈部NEC和SCC碰撞瘤的病例进行了文献综述。
由于存在两种形态学和病因学上截然不同的肿瘤，碰撞瘤的治疗具有挑战性。精心设计的多模式治疗，包括手术和放化疗，可能会使这些患者获得长期生存。
