piRNA在癌症中的生物学功能及分子机制
Biological function and molecular mechanism of piRNA in cancer.
作者信息
Chalbatani Ghanbar Mahmoodi, Dana Hassan, Memari Feridon, Gharagozlou Elahe, Ashjaei Shirin, Kheirandish Peyman, Marmari Vahid, Mahmoudzadeh Habibollah, Mozayani Farnaz, Maleki Ali Reza, Sadeghian Ehsan, Nia Elham Zainali, Miri Seyed Rohollah, Nia Neda Zainali, Rezaeian Omid, Eskandary Anahita, Razavi Narges, Shirkhoda Mohammad, Rouzbahani Fatemeh Nouri
机构信息
Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran.
Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.
出版信息
Pract Lab Med. 2018 Dec 7;13:e00113. doi: 10.1016/j.plabm.2018.e00113. eCollection 2019 Jan.
Cancer is the second leading cause of death globally. piRNAs, which are a novel type of identified small noncoding RNA (ncRNA), play a crucial role in cancer genomics. In recent years, a relatively large number of studies have demonstrated that several piRNA are aberrantly expressed in various kinds of cancers including gastric cancer, bladder cancer, breast cancer, colorectal cancer and Lung cancer and may probably serve as a novel therapeutic target and biomarker for cancer treatment. The present review summarized current advances in our knowledge of the roles of piRNAs in cancer.
癌症是全球第二大死因。piRNA是一种新发现的小型非编码RNA（ncRNA），在癌症基因组学中发挥着关键作用。近年来，大量研究表明，几种piRNA在包括胃癌、膀胱癌、乳腺癌、结直肠癌和肺癌在内的各种癌症中异常表达，可能成为癌症治疗的新型治疗靶点和生物标志物。本综述总结了目前我们对piRNA在癌症中作用的认识进展。
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