Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Biomed Pharmacother. 2017 Dec;96:238-245. doi: 10.1016/j.biopha.2017.09.138. Epub 2017 Oct 6.
Gastric cancer is responsible for approximately one million annual deaths worldwide. Recently, the important roles of miRNAs as vital factors in malignancy processes such as metastasis have identified. They involve in the regulation of different biological procedures such as proliferation, invasion, metastasis and cell survival. MiR-146a has an aberrant expression in different tumors and has different expressions in the gastric cancer cell lines. This microRNA can act as a tumor suppressor and/or oncogene in gastric cancer related cases. Most of the studies have confirmed that miR-146a is downregulated in human gastric cancer cell lines and tissues, significantly and that it has tumor suppressor effects in gastric cancers. On the other hand, the role of miR-146a as an oncogene has been studied in an in-vitro experiment and results showed that over- an expression of miR-146a in gastric cancer tissues inhibits apoptosis and improves cell proliferation of gastric cancer cell. MiR-146a also has been a candidate for diagnosis and prognosis in gastric cancer cases. In this review, we focus on the important roles of miR-146a in tumor genesis of gastric tissues, emphasizing on the involvement of this microRNA in diagnosis, prognosis, chemotherapy response and finally, potential therapeutic applications as an anticancer agent in inhibition of gastric cancer cell metastasis and invasion.
胃癌是全球每年导致约 100 万人死亡的主要原因。最近，miRNA 作为转移等恶性肿瘤过程中的重要因素的重要作用已经得到了确定。它们参与了不同的生物学过程的调节，如增殖、侵袭、转移和细胞存活。miR-146a 在不同的肿瘤中表达异常，在胃癌细胞系中表达也不同。这种 microRNA 可以在胃癌相关病例中作为肿瘤抑制因子和/或癌基因发挥作用。大多数研究已经证实，miR-146a 在人类胃癌细胞系和组织中下调，并且具有肿瘤抑制作用。另一方面，miR-146a 作为癌基因的作用在体外实验中进行了研究，结果表明，在胃癌组织中过表达 miR-146a 可抑制细胞凋亡并提高胃癌细胞的增殖。miR-146a 也被认为是胃癌诊断和预后的候选标志物。在这篇综述中，我们重点关注 miR-146a 在胃癌组织肿瘤发生中的重要作用，强调了这种 microRNA 在诊断、预后、化疗反应中的作用，最后，作为一种抗癌药物，它在抑制胃癌细胞转移和侵袭方面具有潜在的治疗应用。
