Faurholt-Jepsen Maria, Frost Mads, Busk Jonas, Christensen Ellen Margrethe, Bardram Jakob E, Vinberg Maj, Kessing Lars Vedel
Copenhagen Affective Disorder Research Center (CADIC), Psychiatric Center Copenhagen, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
IT University of Copenhagen, Rued Langgaards Vej 7, 2300, Copenhagen, Denmark.
Int J Bipolar Disord. 2019 Feb 1;7(1):5. doi: 10.1186/s40345-019-0141-4.
Mood instability in bipolar disorder is associated with a risk of relapse. This study investigated differences in mood instability between patients with bipolar disorder type I and type II, which previously has been sparingly investigated.
Patients with bipolar disorder type I (n = 53) and type II (n = 31) used a daily smartphone-based self-monitoring system for 9 months. Data in the present reflect 15.975 observations of daily collected smartphone-based data on patient-evaluated mood.
In models adjusted for age, gender, illness duration and psychopharmacological treatment, patients with bipolar disorder type II experienced more mood instability during depression compared with patients with bipolar disorder type I (B: 0.27, 95% CI 0.007; 0.53, p = 0.044), but lower intensity of manic symptoms. Patients with bipolar disorder type II did not experience lower mean mood or higher intensity of depressive symptoms compared with patients with bipolar disorder type I.
Compared to bipolar disorder type I, patients with bipolar disorder type II had higher mood instability for depression. Clinically it is of importance to identify these inter-episodic symptoms. Future studies investigating the effect of treatment on mood instability measures are warranted. Trial registration NCT02221336.
双相情感障碍中的情绪不稳定与复发风险相关。本研究调查了I型和II型双相情感障碍患者在情绪不稳定方面的差异，此前对此研究较少。
I型双相情感障碍患者（n = 53）和II型双相情感障碍患者（n = 31）使用基于智能手机的每日自我监测系统，为期9个月。本研究中的数据反映了对患者评估的情绪进行每日收集的基于智能手机的数据的15975次观察。
在对年龄、性别、病程和心理药物治疗进行调整的模型中，与I型双相情感障碍患者相比，II型双相情感障碍患者在抑郁期间经历了更多情绪不稳定（B：0.27，95%CI 0.007；0.53，p = 0.044），但躁狂症状强度较低。与I型双相情感障碍患者相比，II型双相情感障碍患者的平均情绪并不更低，抑郁症状强度也不更高。
与I型双相情感障碍相比，II型双相情感障碍患者在抑郁时情绪不稳定程度更高。临床上识别这些发作间期症状很重要。有必要开展进一步研究来调查治疗对情绪不稳定指标的影响。试验注册号：NCT02221336。
