Department of Psychiatry, Queen's University, Kingston, ON, Canada.
Mood Disorders Centre of Ottawa, Ottawa, ON, Canada.
Bipolar Disord. 2019 Mar;21(2):159-167. doi: 10.1111/bdi.12721. Epub 2018 Dec 12.
To determine the compliance and clinical utility of weekly and daily electronic mood symptom monitoring in adolescents and young adults at risk for mood disorder.
Fifty emerging adult offspring of bipolar parents were recruited from the Flourish Canadian high-risk offspring cohort study along with 108 university student controls. Participants were assessed by KSADS/SADS-L semi-structured interviews and used a remote capture method to complete weekly and daily mood symptom ratings using validated scales for 90 consecutive days. Hazard models and generalized estimating equations were used to determine differences in summary scores and regularity of ratings.
Seventy-eight and 77% of high-risk offspring and 97% and 93% of controls completed the first 30 days of weekly and daily ratings, respectively. There were no differences in drop-out rates between groups over 90 days (weekly P = 0.2149; daily P = 0.9792). There were no differences in mean summary scores or regularity of weekly anxiety, depressive or hypomanic symptom ratings between high-risk offspring and control groups. However, high-risk offspring compared to controls had daily ratings indicating lower positive affect, higher negative affect and lower self-esteem (P = 0.0317). High-risk offspring with remitted mood disorder compared to those without had more irregularity in weekly anxiety and depressive symptom ratings and daily ratings of lower positive affect, higher negative affect, and higher shame and self-doubt (P = 0.0365).
Findings support that high-resolution electronic mood tracking may be a feasible and clinically useful approach in monitoring emerging psychopathology in young people at high-risk offspring of mood disorder onset or recurrence.
确定每周和每日电子情绪症状监测在有情绪障碍风险的青少年和年轻成人中的依从性和临床实用性。
从 Flourish 加拿大高危后代队列研究中招募了 50 名双相父母的成年后代，以及 108 名大学生对照。参与者通过 KSADS/SADS-L 半结构化访谈进行评估，并使用远程采集方法在连续 90 天内使用经过验证的量表完成每周和每日情绪症状评分。使用风险模型和广义估计方程来确定综合评分和评分规律性的差异。
高危后代中有 78%和 77%，对照中有 97%和 93%分别完成了前 30 天的每周和每日评分。在 90 天内，两组的辍学率没有差异（每周 P=0.2149；每日 P=0.9792）。高危后代和对照组之间的平均综合评分或每周焦虑、抑郁或轻躁狂症状评分的规律性没有差异。然而，与对照组相比，高危后代的每日评分表明积极情绪较低，消极情绪较高，自尊心较低（P=0.0317）。与没有情绪障碍缓解的高危后代相比，有情绪障碍缓解的高危后代在每周焦虑和抑郁症状评分以及每日评分中的积极情绪较低、消极情绪较高、羞耻感和自我怀疑较高方面的不规则性更大（P=0.0365）。
研究结果支持高分辨率电子情绪跟踪可能是监测情绪障碍发病或复发高危后代年轻人出现新兴精神病理学的一种可行且具有临床实用性的方法。
