Muirden K D, Allard S A, Rogers K, Maini R N
Department of Medicine, Royal Melbourne Hospital, Victoria, Australia.
Rheumatol Int. 1988;8(5):231-4. doi: 10.1007/BF00269200.
Immuno-electron microscopy has been utilised to examine the cartilage-pannus junction in seven patients with rheumatoid arthritis. Using a monoclonal antibody, keratan sulphate was localised to cells with the ultra-structural appearance of fibroblasts within a transitional fibroblastic zone in the pannus in two cases. This confirms previous light microscopy evidence that this area (which is clearly separate from articular cartilage) contains cells which produce keratan sulphate, and strengthens the hypothesis that these cells are derived from cartilage rather than from the adjacent synovial membrane.
免疫电子显微镜技术已用于检查7例类风湿性关节炎患者的软骨-血管翳交界处。在两例患者中，使用单克隆抗体将硫酸角质素定位到血管翳中过渡性成纤维细胞区域内具有成纤维细胞超微结构外观的细胞上。这证实了先前光学显微镜检查的证据，即该区域（明显与关节软骨分开）含有产生硫酸角质素的细胞，并强化了这些细胞源自软骨而非相邻滑膜的假说。
