比较伴有和不伴有视网膜病变的糖尿病患者粪便样本与对照受试者的肠道厌氧菌（拟杆菌门）的筛选和鉴定。
Screening and identification of gut anaerobes (Bacteroidetes) from human diabetic stool samples with and without retinopathy in comparison to control subjects.
机构信息
Botany and Microbiology Department, Science College, Female Campus, King Saud University, Riyadh, Saudi Arabia.
Biochemistry Department, College of Sciences, King Saud University, Riyadh, Saudi Arabia.
出版信息
Microb Pathog. 2019 Apr;129:88-92. doi: 10.1016/j.micpath.2019.01.025. Epub 2019 Jan 29.
Studies have reported a reciprocal interaction between metabolic disorders and the human gut microbial composition. However, more information is still needed concerning the gut microbiome related to metabolic disorders such as Diabetes. The aim of the present study was to reveal whether stool samples collected from normal individuals and from diabetic subjects with or without retinopathy differ in their gut microbial composition. Data showed higher Bacteroides ratio in diabetic groups gut composition with no significant difference of bacterial strains in diabetic subjects with or without retinopathy compared to lean (control) individuals gut microbiota. These findings indicated that the gut microbiota is altered in accordance to the presence of metabolic disorders. However, further studies have to be elaborated in terms of gut microbial composition with diabetes.
研究表明代谢紊乱与人类肠道微生物组成之间存在相互作用。然而，关于与代谢紊乱（如糖尿病）相关的肠道微生物组，我们仍需要更多的信息。本研究的目的是揭示来自正常个体和患有糖尿病（有无视网膜病变）个体的粪便样本在肠道微生物组成上是否存在差异。结果表明，糖尿病组的肠道微生物组成中双歧杆菌比例较高，而有或无视网膜病变的糖尿病患者的细菌菌株与瘦（对照）个体的肠道微生物群相比没有显著差异。这些发现表明，肠道微生物群会随着代谢紊乱的出现而发生改变。然而，在糖尿病方面，仍需要进一步研究肠道微生物组成。
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