Haghshenas Leila, Banihashemi Sara, Malekzadegan Yalda, Catanzaro Roberto, Moghadam Ahmadi Amir, Marotta Francesco
Department of Clinical Bioinformatics, Harvard Medical School, Boston, MA 02115, United States.
Department of Bioscience, School of Science and Technology, Nottingham Trend University, Nottingham NG1 4FQ, United Kingdom.
World J Gastrointest Pathophysiol. 2024 Sep 22;15(5):96446. doi: 10.4291/wjgp.v15.i5.96446.
Microbiome is an endocrine organ that refers to both the complicated biological system of microbial species that colonize our bodies and their genomes and surroundings. Recent studies confirm the connection between the microbiome and eye diseases, which are involved in the pathogenesis of eye diseases, including age-related macular disorders, diabetic retinopathy, glaucoma, retinitis pigmentosa, dry eye, and uveitis. The aim of this review is to investigate the microbiome in relation to eye health. First, a brief introduction of the characteristics of the gut microorganisms terms of composition and work, the role of dysbiosis, the gut microbiome and the eye microbiome in the progression of eye illnesses are highlighted, then the relationship among the microbiome and the function of the immune system and eye diseases, the role of inflammation and aging and the immune system, It has been reviewed and finally, the control and treatment goals of microbiome and eye diseases, the role of food factors and supplements, biotherapy and antibiotics in relation to microbiome and eye health have been reviewed.
微生物群是一个内分泌器官，它既指在我们体内定植的微生物物种及其基因组和周围环境组成的复杂生物系统。最近的研究证实了微生物群与眼部疾病之间的联系，微生物群参与眼部疾病的发病机制，包括年龄相关性黄斑病变、糖尿病视网膜病变、青光眼、色素性视网膜炎、干眼症和葡萄膜炎。这篇综述的目的是研究与眼部健康相关的微生物群。首先，简要介绍肠道微生物在组成和作用方面的特征、生态失调的作用、肠道微生物群和眼部微生物群在眼部疾病进展中的作用，然后综述微生物群与免疫系统功能和眼部疾病之间的关系、炎症和衰老以及免疫系统的作用，最后，综述微生物群和眼部疾病的控制与治疗目标、食物因素和补充剂、生物疗法和抗生素在微生物群与眼部健康方面的作用。
