Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, Canada.
Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK.
Curr Opin Struct Biol. 2019 Feb;54:43-49. doi: 10.1016/j.sbi.2018.12.004. Epub 2019 Jan 29.
Tetratricopeptide repeat (TPR) domains and TPR-like domains are widespread across nature. They are involved in varied cellular processes and have been traditionally associated with binding to short linear peptide motifs. However, examples of a much more diverse range of molecular recognition modes are increasing year by year. The Protein Data Bank has an ever-expanding collection of TPR proteins in complex with a myriad of different partners, ranging from short linear peptide motifs to large globular protein domains. In this review, we explore these varied binding modes. Additionally, we hope to highlight an emerging property of this simple, malleable fold-the potential for programmable complexity that can be achieved by acting as a scaffold for multiple binding partners.
四肽重复（TPR）结构域和 TPR 样结构域广泛存在于自然界中。它们参与了多种细胞过程，并且传统上与结合短线性肽基序有关。然而，越来越多的分子识别模式的例子正在逐年增加。蛋白质数据库（PDB）中不断增加的 TPR 蛋白复合物与各种不同的伴侣的集合，从短线性肽基序到大型球状蛋白结构域。在这篇综述中，我们探讨了这些不同的结合模式。此外，我们希望强调这种简单、可塑的折叠的一个新兴特性——通过作为多个结合伴侣的支架，实现可编程复杂性的潜力。
