Beijing Key Labrotary for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology, Beijing 100081, China.
Molecules. 2019 Jan 31;24(3):525. doi: 10.3390/molecules24030525.
Four new glucosyloxybenzyl 2-benzylmalate derivatives, named Arundinoside H (), I (), J (), K () as well as four known compounds Arundinoside D (), G (), F (), E () were isolated and characterized by a combination of chemical and spectroscopic methods, including HR-ESI-MS, 1D and 2D NMR experiments. Besides, 24 unreported compounds were inferred from ESI-MS data. The anti-liver fibrotic activities of the isolates were determined as proliferation inhibition of lipopolysaccharide (LPS)-induced activation of rat hepatic stellate cells (HSC-T6). The result suggested Arundinosides D, H, F, I and K showed moderate inhibitory effects in vitro.
四种新的葡萄糖氧基苄基 2-苄基马来酸酯衍生物，命名为芦丁苷 H（）、I（）、J（）、K（）以及四种已知化合物芦丁苷 D（）、G（）、F（）、E（），通过化学和光谱方法的组合进行了分离和鉴定，包括高分辨电喷雾电离质谱（HR-ESI-MS）、1D 和 2D NMR 实验。此外，还根据 ESI-MS 数据推断出 24 种未报告的化合物。对分离物的抗肝纤维化活性进行了测定，作为脂多糖（LPS）诱导的大鼠肝星状细胞（HSC-T6）激活的增殖抑制。结果表明，芦丁苷 D、H、F、I 和 K 在体外表现出中等抑制作用。
