Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities , Kunming 650031, Yunnan, People's Republic of China.
J Nat Prod. 2013 Oct 25;76(10):1854-9. doi: 10.1021/np400379u. Epub 2013 Sep 24.
Eight new C-4-alkylated deoxybenzoins (1-8), three new diphenylethylenes (9-11), and five known diphenylethylenes were isolated from Arundina graminifolia. The structures of 1-11 were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compounds 9-11 are the first naturally occurring diphenylethylenes possessing a hydroxyethyl unit. Compounds 1-11 were evaluated for cytotoxicity against five human tumor cell lines. Compounds 4, 5, and 9-11 showed significant cytotoxicity against five cancer cell lines, with IC50 values ranging from 1.8 to 8.7 μM.
从 Arundina graminifolia 中分离得到了 8 个新的 C-4-烷基化去氧苯并呋喃（1-8）、3 个新的二苯乙烯（9-11）和 5 个已知的二苯乙烯。通过包括广泛的 1D 和 2D NMR 技术在内的光谱方法阐明了 1-11 的结构。化合物 9-11 是第一个具有羟乙基单元的天然存在的二苯乙烯。对 1-11 进行了对 5 个人类肿瘤细胞系的细胞毒性评估。化合物 4、5 和 9-11 对 5 种癌细胞系表现出显著的细胞毒性，IC50 值范围为 1.8 至 8.7 μM。
