Strasbourg University, Faculty of Pharmacy, UMR 7200, 67400, Illkirch-Graffenstaden, France.
African Genome Center, Mohammed VI Polytechnic University, Ben Guerir, 43150, Morocco; Traditional Thai Medical Research and Innovation Center, Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, 90110, Thailand.
Phytochemistry. 2023 Feb;206:113504. doi: 10.1016/j.phytochem.2022.113504. Epub 2022 Nov 18.
Phytochemical investigation of the underground parts of Arundina graminifolia D.Don Hochr was conducted leading to the isolation of nine new glucosyloxybenzyl 2R-benzylmalate and two new glucosyloxybenzyl 2R-isobutylmalate derivatives. The compounds were purified using chromatographic techniques and their structures were deduced based on spectroscopic techniques including nuclear magnetic resonance and high-resolution mass spectrometry as well as comparing with previous literature. The antioxidant activities of the isolated compounds were also evaluated. The compounds showed potent antioxidant activities in the ABTS radical scavenging, DPPH radical scavenging and FRAP activities. Furthermore, the isolated compounds were observed to exert minimal cytotoxic effects against RAW 264.7 cell, suggesting biocompatibility as well as cytoprotective effects against hydrogen peroxide induced cell toxicity.
对大苞斑叶兰（Arundina graminifolia D.Don Hochr）地下部分进行了植物化学研究，分离得到了 9 个新的葡萄糖氧基苄基 2R-苄基苹果酸和 2 个新的葡萄糖氧基苄基 2R-异丁基苹果酸衍生物。这些化合物通过色谱技术进行了纯化，并根据包括核磁共振和高分辨率质谱在内的光谱技术以及与先前文献的比较，推导出了它们的结构。还评估了分离化合物的抗氧化活性。这些化合物在 ABTS 自由基清除、DPPH 自由基清除和 FRAP 活性方面表现出很强的抗氧化活性。此外，还观察到分离得到的化合物对 RAW 264.7 细胞的细胞毒性作用最小，表明它们具有生物相容性以及对过氧化氢诱导的细胞毒性的细胞保护作用。
