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SWI/SNF复合物缺陷型软组织肿瘤：基于模式的诊断与鉴别诊断方法

SWI/SNF Complex-Deficient Soft Tissue Neoplasms: A Pattern-Based Approach to Diagnosis and Differential Diagnosis.

作者信息

Agaimy Abbas

机构信息

Institute of Pathology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), University Hospital, Krankenhausstrasse 8-10, 91054 Erlangen, Germany.

出版信息

Surg Pathol Clin. 2019 Mar;12(1):149-163. doi: 10.1016/j.path.2018.10.006.

DOI:10.1016/j.path.2018.10.006
PMID:30709441
Abstract

Loss of different components of the Switch/sucrose nonfermentable (SWI/SNF) chromatin remodeling complex has been increasingly recognized as a central molecular event driving the initiation and/or dedifferentiation of mostly lethal but histogenetically diverse neoplasms in different body organs. This review summarizes and discusses the morphologic and phenotypic diversity of primary soft tissue neoplasms characterized by SWI/SNF complex deficiency with an emphasis on convergent and divergent cytoarchitectural patterns.

摘要

开关/蔗糖非发酵型（SWI/SNF）染色质重塑复合体不同组分的缺失，已日益被视为驱动不同身体器官中大多数致命但组织发生学上多样的肿瘤发生起始和/或去分化的核心分子事件。本综述总结并讨论了以SWI/SNF复合体缺陷为特征的原发性软组织肿瘤的形态学和表型多样性，重点关注趋同和不同的细胞结构模式。

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