Carvalho Sofia Daniela, Pissaloux Daniel, Crombé Amandine, Coindre Jean-Michel, Le Loarer François
Department of Pathology, Hospital de Braga, Sete Fontes-Sao Victor, 4710-243 Braga, Portugal; Department of Pathology, Institut Bergonié, 276 cours de l'Argonne, 33000, Bordeaux, France.
Department of Pathology, Centre Leon Berard, Promenade Lea Bullukian, 69376 Lyon, France.
Surg Pathol Clin. 2019 Mar;12(1):63-105. doi: 10.1016/j.path.2018.10.004. Epub 2018 Dec 17.
This article focuses on pleomorphic sarcomas, which are malignant mesenchymal tumors with complex genetic background at the root of their morphologic pleomorphism. They are poorly differentiated tumors that may retain different lines of differentiation, sometimes correlating with clinicopathological or prognostic features. Accurate diagnosis in this group of tumors relies on adequate sampling due to their heterogeneity and assessment with both microscopy and large panels of immunohistochemistry. Molecular analyses have a limited role in their diagnosis as opposed to translocation-related sarcomas but may provide theranostic and important prognostic information in the future.
本文聚焦于多形性肉瘤，它们是恶性间叶性肿瘤，形态多形性的根源在于其复杂的遗传背景。它们是低分化肿瘤，可能保留不同的分化谱系，有时与临床病理或预后特征相关。由于这类肿瘤具有异质性，准确诊断依赖于足够的取材，并结合显微镜检查和大量免疫组化检测进行评估。与易位相关的肉瘤不同，分子分析在其诊断中的作用有限，但未来可能会提供治疗诊断和重要的预后信息。
