Tripathi Sudipta, Guleria Indira
Transplantation Research Center, Harvard Medical School, LMRC #316, 221 Longwood Avenue, Boston, MA 02115, USA.
HLA Tissue Typing Laboratory, Renal Transplant Program, Division of Renal Medicine, Transplantation Research Center, Harvard Medical School, Brigham and Women's Hospital, 75 Francis Street, PBB 161G, Boston, MA 02115, USA.
Clin Lab Med. 2019 Mar;39(1):145-156. doi: 10.1016/j.cll.2018.11.002. Epub 2018 Dec 17.
Multiple mechanisms of tolerance operate in the immune cross-talk at the fetomaternal interface, contributing to successful pregnancy outcome. The cross-talk includes interaction between various cell subsets and between cytokines and molecules of the endocrine system. A depiction of how all these components interact with each other and contribute to tolerance of the fetus is not clearly understood. Dysregulation in one or more of these mechanisms leads to fetal loss. Few effective biomarkers are available that can safely predict fetal loss. This review discusses some potential biomarkers that can predict failure of tolerance at the fetomaternal interface.
多种耐受机制在母胎界面的免疫串扰中发挥作用，有助于实现成功的妊娠结局。这种串扰包括各种细胞亚群之间以及细胞因子与内分泌系统分子之间的相互作用。目前尚不清楚所有这些成分如何相互作用并促成对胎儿的耐受。这些机制中的一种或多种失调会导致胎儿丢失。几乎没有可用的有效生物标志物能够安全地预测胎儿丢失。本综述讨论了一些可能预测母胎界面耐受失败的潜在生物标志物。
