移植后癌症中的信号分子
Signaling Molecules in Posttransplantation Cancer.
作者信息
Balan Murugabaskar, Chakraborty Samik, Pal Soumitro
机构信息
Division of Nephrology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Division of Nephrology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
出版信息
Clin Lab Med. 2019 Mar;39(1):171-183. doi: 10.1016/j.cll.2018.10.006. Epub 2018 Dec 18.
Immunosuppression is essential to prevent graft rejection. However, immunosuppression impairs the ability of the host immune system to control viral infection and decreases tumor immunosurveillance. Therefore, immunosuppression after organ transplantation is a major risk factor for posttransplantation cancer. Notably, recent reports suggest that immunosuppressive agents can activate tumorigenic pathways independent of the involvement of the host immune system. In this review, we focus on cell-intrinsic tumorigenic pathways directly activated by immunosuppressive agents and discuss the much-described infection- and immune-mediated mechanisms of cancer development in organ transplant recipients.
免疫抑制对于预防移植物排斥至关重要。然而，免疫抑制会损害宿主免疫系统控制病毒感染的能力，并降低肿瘤免疫监视功能。因此，器官移植后的免疫抑制是移植后发生癌症的主要危险因素。值得注意的是，最近的报告表明，免疫抑制剂可独立于宿主免疫系统的参与而激活致瘤途径。在本综述中，我们重点关注由免疫抑制剂直接激活的细胞内在致瘤途径，并讨论器官移植受者中被广泛描述的感染和免疫介导的癌症发生机制。
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