University of Heidelberg, Department of Oral and Cranio-Maxillofacial Surgery, Im Neuenheimer Feld 400, D-69120, Heidelberg, Germany.
University of Würzburg, Department of Oral and Maxillofacial Plastic Surgery, Pleicherwall 2, D-97070, Würzburg, Germany.
J Craniomaxillofac Surg. 2019 Mar;47(3):523-529. doi: 10.1016/j.jcms.2019.01.015. Epub 2019 Jan 17.
Locoregional disease recurrence and metastatic events are the leading causes of death and the most important prognostic factors in patients with head and neck squamous cell carcinoma (HNSCC). A major goal of oncology is the identification of clinical and molecular parameters to evaluate the individual risk of recurrence. MicroRNAs (miRNAs) have been shown to correlate well with tumor size and differentiation. Therefore, they are candidate biomarkers for estimating clinical outcomes.
In this study, the expression levels of distinct miRNAs extracted from formalin-fixed, paraffin-embedded (FFPE) samples of oral squamous cell carcinoma were compared.
Statistical analysis revealed significant correlations between distinct miRNAs and disease recurrence (miR-99*, miR-194*; p < 0.05) and overall survival (miR-99*; p < 0.05). The results were then validated via data from The Cancer Genome Atlas (TCGA).
Our data show that miR-99* and miR-194* can possibly serve as biomarkers for clinical outcome in HNSCC. These findings may help to identify high-risk patients, who could profit from a more individualized treatment and follow-up.
局部区域疾病复发和转移事件是头颈部鳞状细胞癌（HNSCC）患者死亡的主要原因和最重要的预后因素。肿瘤学的主要目标是确定临床和分子参数，以评估个体复发风险。microRNAs（miRNAs）已被证明与肿瘤大小和分化密切相关。因此，它们是估计临床结果的候选生物标志物。
本研究比较了从福尔马林固定、石蜡包埋（FFPE）的口腔鳞状细胞癌样本中提取的不同 miRNAs 的表达水平。
统计分析显示，不同的 miRNAs 与疾病复发（miR-99*，miR-194*；p<0.05）和总生存（miR-99*；p<0.05）之间存在显著相关性。然后通过癌症基因组图谱（TCGA）的数据进行验证。
我们的数据表明，miR-99和 miR-194可能可作为 HNSCC 临床结果的生物标志物。这些发现可能有助于识别高风险患者，他们可能从更个体化的治疗和随访中受益。
