Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio 44195.
J Biol Chem. 2019 Feb 1;294(5):1690-1696. doi: 10.1074/jbc.TM118.005836.
Hyaluronan has a very simple structure. It is a linear glycosaminoglycan composed of disaccharide units of GlcNAc and d-glucuronic acid with alternating β-1,4 and β-1,3 glycosidic bonds that can be repeated 20,000 or more times, a molecular mass >8 million Da, and a length >20 μm. However, it has a very complex biology. It is a major, ubiquitous component of extracellular matrices involved in everything from fertilization, development, inflammations, to cancer. This JBC Review highlights some of these processes that were initiated through publications in the .
透明质酸具有非常简单的结构。它是一种线性糖胺聚糖，由 GlcNAc 和 d-葡萄糖醛酸的二糖单元组成，通过β-1,4 和β-1,3 糖苷键交替连接，可重复 20000 次以上，分子量>800 万 Da，长度>20 μm。然而，它具有非常复杂的生物学特性。它是细胞外基质的主要、普遍组成成分，参与从受精、发育、炎症到癌症等各种过程。这篇 JBC 综述重点介绍了通过. 发表的论文而开始的这些过程中的一部分。
