Ambartsumian Noona, Klingelhöfer Jörg, Grigorian Mariam
Faculty of Health, Department of Neuroscience, Copenhagen University, Copenhagen, Denmark.
Methods Mol Biol. 2019;1929:339-365. doi: 10.1007/978-1-4939-9030-6_22.
The metastasis-promoting S100A4 protein, a member of the S100 family, has recently been discovered as a potent factor implicated in various inflammation-associated diseases. S100A4 is involved in a range of biological functions such as angiogenesis, cell differentiation, apoptosis, motility, and invasion. Moreover, S100A4 is also a potent trigger of inflammatory processes and induces the release of cytokines and growth factors under different pathological conditions.Indeed, the release of S100A4 upon stress and mainly its pro-inflammatory role emerges as the most decisive activity in disease development, such as rheumatoid arthritis (RA), systemic sclerosis (SSc) allergy, psoriasis, and cancer. In the scope of this review, we will focus on the role of S100A4 as a mediator of pro-inflammatory pathways and its associated biological processes involved in the pathogenesis of various human noncommunicable diseases (NCDs) including cancer.
促转移蛋白S100A4是S100家族的成员之一，最近被发现是一种与多种炎症相关疾病有关的重要因子。S100A4参与一系列生物学功能，如血管生成、细胞分化、凋亡、运动和侵袭。此外，S100A4也是炎症过程的有效触发因素，并在不同病理条件下诱导细胞因子和生长因子的释放。事实上，应激时S100A4的释放及其主要的促炎作用是疾病发展中最具决定性的活动，如类风湿性关节炎（RA）、系统性硬化症（SSc）、过敏、银屑病和癌症。在本综述范围内，我们将重点关注S100A4作为促炎途径介质的作用及其参与包括癌症在内的各种人类非传染性疾病（NCD）发病机制的相关生物学过程。
