Clinic of Preventive Dentistry, Periodontology and Cariology, Center of Dental Medicine, University of Zürich, Plattenstrasse 33, 8032, Zürich Switzerland.
Department of Operative Dentistry and Periodontology, School of Dental Medicine, Martin-Luther-University, Magdeburger Strasse 16, 06120, Halle, Germany.
J Dent. 2019 Apr;83:1-6. doi: 10.1016/j.jdent.2019.01.002. Epub 2019 Jan 30.
To assess the efficacy of 8% arginine containing prophylaxis products over 24 weeks in subjects with dentin hypersensitivity (DH).
297 patients with established DH (Schiff score 2, 3) in three European study centers were randomly assigned to either 8% arginine and calcium carbonate in-office prophylaxis paste and the respective toothpaste (test group) or fluoride-free prophylaxis paste and sodium monoflourophosphate toothpaste as a negative control group. Air blast (Schiff Score) and tactile (Visual Analog Scale) sensitivity scores were assessed at baseline (BL_0), after single application of the prophylaxis paste (BL_1) and after 4, 8, and 24 weeks of continuous at-home use of the toothpaste.
273 subjects completed the study. Test and control group presented statistically significant percentage reductions (t-test, p < 0.05) in Schiff Score at BL_1 and at 24 weeks relative to BL_0 (difference in %; test group: -23.6, -44.9, control group: -8.8, -32.7). The pooled Schiff Score for the two evaluated teeth yielded a significantly greater alleviation of DH in the test group than in the control group at all evaluation appointments (Ancova, p < 0.05; difference in %: 15.3, 7.4, 10.6, 17.2).
A significant relief of DH was demonstrated after application of the 8% arginine prophylaxis products over 24 weeks compared to a negative control.
Whilst DH is influencing patients' eating, drinking and tooth brushing habits as well as social life interactions it is important that clinicians are able to offer evidence based immediate and long-lasting treatment methods in order to manage their patients' discomfort.
评估 8%精氨酸含预防产品在 24 周内对牙本质敏感（DH）患者的疗效。
3 个欧洲研究中心的 297 名确诊 DH 患者（Schiff 评分 2、3）随机分为 8%精氨酸和碳酸钙诊室预防膏和相应牙膏（试验组）或无氟预防膏和单氟磷酸钠牙膏（阴性对照组）。在基线（BL_0）、单次应用预防膏后（BL_1）以及连续使用牙膏 4、8 和 24 周后，使用空气喷射（Schiff 评分）和触觉（视觉模拟评分）敏感性评分评估。
273 名患者完成了研究。与 BL_0 相比，试验组和对照组在 BL_1 和 24 周时的 Schiff 评分均呈现出统计学上显著的百分比降低（t 检验，p < 0.05）（差异百分比；试验组：-23.6、-44.9，对照组：-8.8、-32.7）。对两颗评估牙齿的汇总 Schiff 评分表明，在所有评估时间点，试验组比对照组对 DH 的缓解程度更大（协方差分析，p < 0.05；差异百分比：15.3、7.4、10.6、17.2）。
与阴性对照组相比，8%精氨酸预防产品应用 24 周后，DH 明显缓解。
虽然 DH 影响患者的饮食、饮水和刷牙习惯以及社交生活互动，但临床医生能够提供基于证据的即时和长期治疗方法来管理患者的不适非常重要。
