Lee Erica B, Reynolds Kelly A, Pithadia Deeti J, Wu Jashin J
Dermatology Research and Education Foundation, Irvine, California.
Dermatol Online J. 2019 Jan 15;25(1):13030/qt0pc0g809.
Development of lentigines in areas of resolving psoriatic plaques is a rare phenomenon that has been reported following various treatment modalities including phototherapy, topical therapies, and biologics. Although the exact mechanism is unknown, evidence suggests that the cause may be multifactorial, with factors such as skin type, sun exposure, inflammation, and immunologic cytokines all playing a potential role. Herein, we present the first reported case of a patient developing multiple lentigines following treatment of psoriasis with the IL-23 inhibitor guselkumab.
在银屑病斑块消退区域出现雀斑样痣是一种罕见现象，在包括光疗、局部治疗和生物制剂在内的各种治疗方式后均有报道。尽管确切机制尚不清楚，但有证据表明其原因可能是多因素的，皮肤类型、阳光照射、炎症和免疫细胞因子等因素都可能发挥潜在作用。在此，我们报告首例在用白细胞介素-23抑制剂古塞库单抗治疗银屑病后出现多发性雀斑样痣的患者。
