Institute of Dermatology, Guangzhou Medical University, Guangzhou, China.
Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou, China.
Dermatol Ther. 2021 Sep;34(5):e15048. doi: 10.1111/dth.15048. Epub 2021 Jul 7.
Psoriasis is a systemic inflammatory disease commonly associated with postinflammatory hyper- and hypo-pigmentation. Psoriasis-related cytokines such as IL-17 and TNF can contribute to these pigmentation changes by regulating both the growth and pigment production of melanocytes. Here, we present the first reported the case of a patient with a 10-year history of severe psoriasis vulgaris, who developed multiple lentigines in areas of resolved psoriatic plaques during anti-IL-17A antibody secukinumab.
银屑病是一种常见的系统性炎症性疾病，常伴有炎症后色素沉着过度和色素减退。银屑病相关的细胞因子，如白细胞介素-17（IL-17）和肿瘤坏死因子（TNF），可以通过调节黑素细胞的生长和色素生成来导致这些色素变化。在这里，我们报告了首例接受抗白细胞介素-17A 抗体司库奇尤单抗治疗的 10 年重度寻常型银屑病患者，在银屑病斑块消退区域出现多处雀斑样痣的病例。
