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帕金森病自主神经功能障碍的识别与治疗

Recognition and treatment of autonomic disturbances in Parkinson's disease.

作者信息

Li Kai, Reichmann Heinz, Ziemssen Tjalf

机构信息

a 1 Center of Clinical Neuroscience, Technical University Dresden, Dresden, Germany.

b 2 Department of Neurology, Technical University Dresden, Dresden, Germany.

出版信息

Expert Rev Neurother. 2015 Oct;15(10):1189-203. doi: 10.1586/14737175.2015.1095093.

Abstract

Symptoms of dysautonomia are common in Parkinson's disease (PD), and almost all the functional autonomic subsystems can be involved in PD. However, they are still under-recognized in everyday clinical practice. Autonomic dysfunction can be observed in the early stages of PD, affect a substantial proportion of patients, impact quality of life and can also help in differential diagnosis. This review aims to provide an overview of the pathophysiology, clinical manifestations, relevant examination and treatment of cardiovascular, gastrointestinal, urogenital, thermoregulatory and pupil autonomic dysfunctions in Parkinson's disease.

摘要

自主神经功能障碍的症状在帕金森病(PD)中很常见,几乎所有功能性自主神经子系统都可能累及PD。然而,在日常临床实践中它们仍未得到充分认识。自主神经功能障碍在PD早期即可观察到,影响相当一部分患者,影响生活质量,还有助于鉴别诊断。本综述旨在概述帕金森病中心血管、胃肠道、泌尿生殖、体温调节及瞳孔自主神经功能障碍的病理生理学、临床表现、相关检查及治疗。

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