水牛α疱疹病毒1在山羊中引发潜伏/可再激活感染。

Bubaline alphaherpesvirus 1 induces a latent/reactivable infection in goats.

作者信息

Camero M, Lanave G, Lucente M S, Losurdo M, Di Paola G, Lorusso E, Martella V, Buonavoglia C, Tempesta M

机构信息

Department of Veterinary Medicine, University of Bari, Sp. Casamassima km 3, Valenzano 70010, Italy.

出版信息

Comp Immunol Microbiol Infect Dis. 2019 Feb;62:54-57. doi: 10.1016/j.cimid.2018.11.010. Epub 2018 Nov 28.

DOI:10.1016/j.cimid.2018.11.010

PMID:30711046

Abstract

Latent infection is a common mechanism used by several alphaherpesviruses to persist in their host but it is not clear whether this mechanism is also triggered in heterologous infections. Cross-species infections have been documented repeatedly for alphaherpesviruses of ruminants, a group of closely related viruses. Herewith we report latent infection with bubaline alphaherpesvirus 1 (BuHV-1) in experimentally infected goats and subsequent virus reactivation after treatment with dexamethasone (DMS) at 10 months after infection. After DMS treatment, the virus was isolated in one such animal in the nasal swabs from day 3 to 9 post treatment and in the ocular swabs at day 6. The goat was euthanized 48 days after DMS treatment and viral DNA was detected by PCR in the trigeminal ganglia and in two cervical ganglia. Additionally, BuHV-1 DNA was detected by PCR in the trigeminal ganglia of the other 3 goats.

摘要

潜伏感染是几种α疱疹病毒在其宿主中持续存在的常见机制，但尚不清楚这种机制在异源感染中是否也会被触发。反刍动物的α疱疹病毒是一组密切相关的病毒，跨物种感染已被多次记录。在此，我们报告了在实验感染的山羊中感染了水牛α疱疹病毒1型（BuHV-1），并在感染后10个月用地塞米松（DMS）治疗后病毒重新激活。DMS治疗后，在一只这样的动物中，从治疗后第3天到第9天在鼻拭子中分离到病毒，在第6天在眼拭子中分离到病毒。DMS治疗48天后对山羊实施安乐死，并通过PCR在三叉神经节和两个颈神经节中检测到病毒DNA。此外，通过PCR在其他3只山羊的三叉神经节中检测到了BuHV-1 DNA。