无症状钩端螺旋体感染与犬慢性肾病有关。
Asymptomatic leptospiral infection is associated with canine chronic kidney disease.
作者信息
Sant'Anna R, Vieira A S, Oliveira J, Lilenbaum W
机构信息
Department of Microbiology and Parasitology, Biomedical Institute of the Fluminense Federal University, Brazil.
Department of Pathology and Clinics, Fluminense Federal University, Brazil.
出版信息
Comp Immunol Microbiol Infect Dis. 2019 Feb;62:64-67. doi: 10.1016/j.cimid.2018.11.009. Epub 2018 Nov 24.
Canine leptospirosis is characterized by an acute or chronic disease. Some dogs may act as asymptomatic carriers, keeping the agent in the renal tubules and eliminating it in the urine for an extended period. Chronic kidney disease (CKD) is multifactorial and pathophysiology has been widely discussed. The aim of the study was to investigate whether the occurrence of CKD may possibly be associated with asymptomatic leptospiral infection in dogs in endemic regions. Serology and urine PCR were performed in 16 dogs with CKD and 48 healthy dogs from an endemic area. Dogs with CKD were more frequently shedders (75%) than non-CKD animals (20.8%). Therefore, our results demonstrate that asymptomatic leptospiral infection is associated with canine chronic kidney disease and that differential diagnosis is important for dogs from endemic areas presenting CKD. The early detection of shedders, besides the obvious impact on Public health may also help to improve the animal health and avoid the development of CKD.
犬钩端螺旋体病的特征是急性或慢性疾病。一些犬可能作为无症状携带者，将病原体保留在肾小管中，并在尿液中长期排出。慢性肾脏病（CKD）是多因素的，其病理生理学已被广泛讨论。本研究的目的是调查在流行地区，CKD的发生是否可能与犬的无症状钩端螺旋体感染有关。对来自流行地区的16只患有CKD的犬和48只健康犬进行了血清学和尿液PCR检测。患有CKD的犬比非CKD动物更频繁地排出病原体（75%对20.8%）。因此，我们的结果表明，无症状钩端螺旋体感染与犬慢性肾脏病有关，对于来自流行地区出现CKD的犬，鉴别诊断很重要。除了对公共卫生有明显影响外，早期检测出排出病原体的犬也可能有助于改善动物健康并避免CKD的发展。
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