Department of Biological Sciences, Okinawa Prefectural Institute of Health and Environment, Okinawa, Japan.
Yanbaru Animal Clinic, Okinawa, Japan.
J Vet Med Sci. 2022 Sep 21;84(10):1324-1327. doi: 10.1292/jvms.22-0287. Epub 2022 Aug 25.
A 2-year-old male mongoose-scat-detection dog was diagnosed with leptospirosis by urine PCR. The patient developed acute renal failure, hepatic dysfunction, and disseminated intravascular coagulation. Treatment with antibiotics was administered, including ampicillin and doxycycline, and supportive care management was provided. Seroconversion against serogroup Hebdomadis was observed on day 8. The leptospiral gene flaB was detected only in urine collected on day 1, from which Leptospira interrogans ST329 was identified by multilocus sequence typing using seven housekeeping genes. L. interrogans serogroup Hebdomadis ST329 has been isolated from mongooses and humans in Okinawa, Japan. This patient received early treatment with antibiotics, which may have contributed to the early recovery of renal function and removal of L. interrogans from kidney tissue.
一只两岁大的雄性猫鼬粪便检测犬通过尿液 PCR 被诊断患有钩端螺旋体病。该患者出现急性肾衰竭、肝功能障碍和弥散性血管内凝血。给予包括氨苄西林和强力霉素在内的抗生素治疗，并提供支持性护理管理。第 8 天观察到针对血清群 Hebdomadis 的血清转化。仅在第 1 天采集的尿液中检测到钩端螺旋体 flaB 基因，通过使用 7 个管家基因的多位点序列分型鉴定出 Leptospira interrogans ST329。日本冲绳的猫鼬和人类中已分离出 L. interrogans 血清群 Hebdomadis ST329。该患者接受了早期抗生素治疗，这可能有助于肾功能的早期恢复和肾脏组织中 L. interrogans 的清除。
