Watanabe Akira, Harimoto Norihumi, Araki Kenichiro, Kubo Norio, Igarashi Takamichi, Tsukagoshi Mariko, Ishii Norihiro, Yamanaka Takahiro, Yoshizumi Tomoharu, Shirabe Ken
Department of Hepatobiliary and Pancreatic Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.
Department of Hepatobiliary and Pancreatic Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan
Anticancer Res. 2019 Feb;39(2):941-947. doi: 10.21873/anticanres.13197.
BACKGROUND/AIM: Intrahepatic cholangiocarcinoma (IHCC) is characterized by poor prognosis, and postoperative recurrence remains a problem. Thus, prognostic markers for IHCC are greatly needed. Recently, inflammatory factors were reported to be related to tumor progression and recurrence in various cancers. Therefore, the present study aimed to evaluate the prognostic ability of inflammatory factors.
Forty-four patients with mass-forming IHCC (m-IHCC) were retrospectively evaluated and the correlations between inflammatory markers, including neutrophil-to-lymphocyte ratio and, modified Glasgow prognostic score, and patient survival were assessed.
The absolute neutrophil count (ANC) was significantly higher in the recurrence group than in the non-recurrence group (p=0.00568) and the most significant prognostic factor by multivariate analysis. Poor recurrence-free survival (RFS; p=0.00452) and cancer-specific survival (CSS; p=0.0323) were associated with high neutrophil levels. Moreover, neutrophil infiltration in the tumor site was positively correlated with ANC.
ANC is associated with poor RFS, and could be used to predict recurrence in patients with m-IHCC.
背景/目的：肝内胆管癌（IHCC）预后较差，术后复发仍是一个问题。因此，非常需要IHCC的预后标志物。最近，有报道称炎症因子与各种癌症的肿瘤进展和复发有关。因此，本研究旨在评估炎症因子的预后能力。
回顾性评估44例肿块型IHCC（m-IHCC）患者，评估炎症标志物（包括中性粒细胞与淋巴细胞比值和改良格拉斯哥预后评分）与患者生存率之间的相关性。
复发组的绝对中性粒细胞计数（ANC）显著高于未复发组（p = 0.00568），且是多因素分析中最显著的预后因素。中性粒细胞水平高与无复发生存期（RFS；p = 0.00452）和癌症特异性生存期（CSS；p = 0.0323）差相关。此外，肿瘤部位的中性粒细胞浸润与ANC呈正相关。
ANC与较差的RFS相关，可用于预测m-IHCC患者的复发。
