Department of Pediatrics/Division of Neonatology, Medical University of South Carolina, Charleston, SC, USA.
Department of Pharmaceutical Sciences, University of South Florida and James A. Haley VA Medical Center, Tampa, FL, USA.
Pediatr Res. 2019 Nov;86(5):662-669. doi: 10.1038/s41390-019-0322-y. Epub 2019 Feb 2.
Polymorphic alleles of the vitamin D (vitD)-binding protein (VDBP) gene are associated with discriminatory differences in circulating concentrations of 25-hydroxyvitamin D (25-D), the indicator of vitD status (sufficiency defined by the Endocrine Society as ≥75 nmol/L). Within a diverse group of children, we hypothesized that reaching recommended daily allowance (RDA) of vitD intake would have differential impact on vitD status depending on VDBP variability.
VDBP alleles (Gc1S, Gc1F, Gc2) in 123 children (1-4 annual visits/child; ages 1-8 years) were compared for relationships with serum 25-D concentrations and daily vitD intake.
In African-American children, reaching the vitD RDA was associated with significantly higher mean serum 25-D concentrations for the 20% carrying the VDBP 1S allele than for the large majority without this allele (77 vs. 61 nmol/L 25-D; p = 0.038). Children with the Gc1S/1S homozygous genotype (30% Caucasians, 24% Hispanics, 2% African-Americans) who met RDA had 51% (39 nmol/L) greater mean serum 25-D than those below RDA (p < 0.0001).
VDBP genetic variability was a significant factor affecting childhood vitD status when following RDA guidelines. This study may inform public health policy of uniformity in recommended childhood vitD dosage, especially regarding racially/ethnically associated disparities.
维生素 D（vitD）结合蛋白（VDBP）基因的多态性等位基因与循环 25-羟维生素 D（25-D）浓度的鉴别差异有关，25-D 是 vitD 状态的指标（内分泌学会定义为≥75nmol/L 为充足）。在一个多样化的儿童群体中，我们假设根据 VDBP 变异性，达到推荐的每日摄入量（RDA）vitD 摄入会对 vitD 状态产生不同的影响。
比较了 123 名儿童（每个儿童 1-4 次年度就诊；年龄 1-8 岁）的 VDBP 等位基因（Gc1S、Gc1F、Gc2）与血清 25-D 浓度和每日 vitD 摄入量的关系。
在非裔美国儿童中，达到 vitD RDA 与携带 VDBP 1S 等位基因的儿童（20%）的平均血清 25-D 浓度显著升高，而不携带该等位基因的大多数儿童（77 比 61nmol/L 25-D；p=0.038）。符合 RDA 的 Gc1S/1S 纯合基因型（30%的白种人、24%的西班牙裔、2%的非裔美国人）儿童的平均血清 25-D 比不符合 RDA 的儿童高 51%（39nmol/L；p<0.0001）。
当遵循 RDA 指南时，VDBP 遗传变异性是影响儿童 vitD 状态的重要因素。这项研究可能为儿童 vitD 推荐剂量的统一提供公共卫生政策信息，特别是关于与种族/民族相关的差异。
