Park Jung-Hoon, Bakheet Nader, Na Hee Kyong, Jeon Jae Yong, Yoon Sung Hwan, Kim Kun Yung, Zhe Wang, Kim Do Hoon, Jung Hwoon-Yong, Song Ho-Young
Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Republic of Korea.
Department of Biomedical Engineering Research Center, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Republic of Korea.
Obes Surg. 2019 May;29(5):1521-1527. doi: 10.1007/s11695-018-03692-5.
To evaluate the technical feasibility, safety, and efficacy of a novel full sense device (FSD) for the treatment of obesity in a porcine model.
The novel FSD comprised a self-expanding metallic esophageal stent connected to a star-shaped nitinol disk. Three types of FSD were used: fully covered (type A), fully covered with barbs (type B), and uncovered with barbs (type C). Nine juvenile pigs were divided into two groups: FSD (n = 6) and control (n = 3). FSD type A was placed in the FSD group. In case of migration, either FSD type B or type C was then randomly placed. Food intake was monitored daily. Weight changes and ghrelin hormone levels were monitored weekly for 12 weeks.
FSD placement was technically successful in all pigs. All FSDs except one migrated to the stomach within 1 week after placement. The pig in which the FSD was retained showed decreased food intake in the first week after FSD placement, and there was a difference in the final weight between the FSD pig and control pigs. The percentage of weight gain was 116.6% in the control group and 105.3% in the FSD pig.
FSD placement under fluoroscopic and endoscopic guidance is technically feasible and safe in a porcine model. The uncovered FSD appears to decrease food intake and reduce the rate of weight gain. However, the high FSD migration rate is not encouraging.
评估一种新型全感知装置（FSD）在猪模型中治疗肥胖症的技术可行性、安全性和有效性。
新型FSD由连接到星形镍钛合金盘的自膨胀金属食管支架组成。使用了三种类型的FSD：完全覆盖型（A型）、带倒刺的完全覆盖型（B型）和带倒刺的未覆盖型（C型）。9只幼年猪分为两组：FSD组（n = 6）和对照组（n = 3）。FSD组植入A型FSD。若发生移位，则随机植入B型或C型FSD。每天监测食物摄入量。每周监测体重变化和胃饥饿素激素水平，持续12周。
所有猪的FSD植入在技术上均获成功。除1只外，所有FSD在植入后1周内均移至胃内。FSD未移位的猪在FSD植入后的第一周食物摄入量减少，FSD猪与对照猪的最终体重存在差异。对照组体重增加百分比为116.6%，FSD猪为105.3%。
在透视和内镜引导下进行FSD植入在猪模型中技术上可行且安全。未覆盖的FSD似乎可减少食物摄入量并降低体重增加率。然而，FSD的高移位率并不乐观。
