Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuan Nanli, Chaoyang District, Beijing, 100021, China.
Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea.
Surg Endosc. 2021 Mar;35(3):1052-1057. doi: 10.1007/s00464-020-07467-x. Epub 2020 Feb 24.
An intragastric satiety-inducing device (ISD) (Full Sense Device; Baker, Foote, Kemmeter, Walburn, LLC, Grand Rapids, MI) is a novel weight-loss device, which may induce satiety by applying continuous pressure on the gastric cardia. This study investigated the effect of the ISD on food intake and body weight gain in a rodent model.
Thirty-two male Sprague-Dawley rats (weight, 250-300 g) were randomly divided into four groups of eight individuals. Single-disk (SD) and double-disk (DD) group animals underwent peroral placement of a single- or double-disk ISD, respectively, under fluoroscopic guidance. The ISD comprised a 4 mm × 1.5 cm nitinol stent placed in the lower esophagus and one (single-disk) or two (double-disk) 2.5-cm-diameter star-shaped nitinol disks placed in the gastric fundus. Esophageal stent (ES) and sham-operated (SO) group animals underwent peroral placement of the ES part of the ISD and a sham operation, respectively.
Food intake was significantly different among the four groups over the 4-week study period (P < 0.001); food intake was significantly lower in the SD and DD groups than in the SO group (P = 0.016 and P = 0.002, respectively) but was not significantly different between the SD and DD groups (P > 0.999) and between the ES and SO groups (P = 0.677). Body weight was significantly different among the four groups by the end of the study period (P < 0.001); body weight was significantly lower in the DD group than in the SD, ES, and SO groups (P = 0.010, P < 0.001, and P < 0.001, respectively) and in the SD group than in the SO group (P = 0.001), but it was not significantly different between the ES and SO groups (P = 0.344).
ISD reduced food intake and suppressed body weight gain in a rodent model.
胃内饱腹感诱导装置（ISD）（Full Sense Device；Baker、Foote、Kemmeter、Walburn，LLC，Grand Rapids，MI）是一种新型的减肥装置，它通过对胃贲门施加持续压力来引起饱腹感。本研究旨在通过动物模型探讨 ISD 对食物摄入和体重增加的影响。
32 只雄性 Sprague-Dawley 大鼠（体重 250-300g）随机分为四组，每组 8 只。单盘（SD）和双盘（DD）组动物在透视引导下经口放置单盘或双盘 ISD。ISD 由一个放置在下食管的 4mm×1.5cm 镍钛诺支架和一个放置在胃底的两个 2.5cm 直径星形镍钛诺盘组成。食管支架（ES）和假手术（SO）组动物分别经口放置 ISD 的 ES 部分和假手术。
在 4 周的研究期间，四组动物的食物摄入量存在显著差异（P<0.001）；SD 和 DD 组的食物摄入量明显低于 SO 组（P=0.016 和 P=0.002），但 SD 和 DD 组之间（P>0.999）以及 ES 和 SO 组之间（P=0.677）无显著差异。研究结束时，四组动物的体重存在显著差异（P<0.001）；DD 组的体重明显低于 SD、ES 和 SO 组（P=0.010、P<0.001 和 P<0.001）以及 SD 组（P=0.001），但 ES 和 SO 组之间无显著差异（P=0.344）。
ISD 可减少动物模型的食物摄入并抑制体重增加。
