a Instituto de Investigación e Innovación en Salud Integral, Facultad de Ciencias Médicas , Universidad Católica de Santiago de Guayaquil , Guayaquil , Ecuador.
b Department of Obstetrics and Gynecology , University of Zaragoza Faculty of Medicine and Lozano-Blesa University Hospital , Zaragoza , Spain.
Climacteric. 2019 Apr;22(2):127-132. doi: 10.1080/13697137.2018.1561666. Epub 2019 Feb 4.
The metabolic syndrome (METS) is an entity diagnosed by three or more of the following factors: abdominal obesity, low high-density lipoprotein cholesterol, and high serum triglycerides, fasting glucose, and/or blood pressure levels. Abdominal obesity is the most prevalent component of the syndrome that favors insulin resistance and a proinflammatory and prothrombotic status, and the risk of developing diabetes, hypertension, and other chronic conditions. During the menopausal transition, women tend to gain weight and this has been related to an increase in the prevalence of the METS. Rates have also been linked to hormonal status (perimenopausal vs. postmenopausal), changes in lifestyle, and endocrine adjustments. Abnormal cytokine secretion subsequently produces endothelial dysfunction, which will consequently increase cardiovascular risk and related morbidity and mortality. This document will review the various risks that arise as a consequence of the METS during female midlife.
代谢综合征（METS）是通过以下三个或更多因素诊断出的一种病症：腹部肥胖、低高密度脂蛋白胆固醇和高血清甘油三酯、空腹血糖和/或血压水平。腹部肥胖是该综合征最常见的组成部分，它有利于胰岛素抵抗以及促炎和促血栓形成状态，并且增加了发生糖尿病、高血压和其他慢性疾病的风险。在绝经过渡期间，女性往往会体重增加，这与 METS 的患病率增加有关。发病率还与激素状态（围绝经期与绝经后）、生活方式的改变和内分泌调节有关。异常细胞因子的分泌随后会导致内皮功能障碍，这将增加心血管风险以及相关的发病率和死亡率。本文将综述女性中年时期代谢综合征带来的各种风险。
