Grupo de Estudios Epidemiológicos y Salud Pública, Heart Failure and Heart Transplant Clinic, Fundacion Cardiovascular de Colombia, Calle 155 A No. 23-58, Urbanizacion El Bosque, Floridablanca, Santander, Colombia.
Division of Cardiology, Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Foothills Medical Centre, Room C823, 1403 29th Street Northwest, Calgary, Alberta T2N 2T9, Canada.
Infect Dis Clin North Am. 2019 Mar;33(1):119-134. doi: 10.1016/j.idc.2018.10.015.
American trypanosomiasis is caused by a parasite endemic of the Americas. Current migration has globalized Chagas disease. Acute infection usually resolves spontaneously. Nonetheless, 20% to 40% develop cardiomyopathy 20 to 30 years later. Progression to cardiomyopathy is devastatingly rapid, manifesting with heart failure and sudden death. Etiologic treatment is highly effective and recommended in those with acute infections, congenital infections, and parasite reactivation, and women of childbearing age, but in asymptomatic Trypanosoma cruzi carriers and patients with early cardiomyopathy remains controversial and under investigation. Progression of heart failure is rapid and accounts for most of the morbidity and related mortality.
美洲锥虫病由美洲特有的寄生虫引起。目前的移民潮使恰加斯病全球化。急性感染通常会自行消退。然而，20%到 40%的人在 20 到 30 年后会发展为心肌病。进展为心肌病的速度非常快，表现为心力衰竭和猝死。病因治疗在急性感染、先天性感染和寄生虫再激活以及育龄妇女中非常有效且推荐，但在无症状的克氏锥虫携带者和早期心肌病患者中仍存在争议，且正在研究中。心力衰竭的进展迅速，是导致大多数发病率和相关死亡率的主要原因。
