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[儿童肝移植。欧洲的情况及首批100例患者的个人结果]

[Liver transplantation in the child. The situation in Europe and personal results of the first 100 patients].

作者信息

Otte J B, de Ville de Goyet J, de Hemptinne B, Moulin D, Claus D, Clapuyt P, Rahier J, Veyckmans F, Carlier M A, Van Obberg L

机构信息

Service de Chirurgie Pédiatrique, Cliniques Universitaires Saint-Luc.

出版信息

Arch Fr Pediatr. 1988;45 Suppl 1:719-25.

PMID:3071291
Abstract

Pediatric liver transplantation in Europe has expanded rapidly during the last four years. The survival rate of the 254 children less than 15 years recorded in the European Registry on December 31, 1987 was 68% at one year and 61% at three years; nineteen centers have contributed to this activity, of which 11 had performed less than 5 cases each while two thirds of the experience was concentrated in three centers (Brussels, Cambridge, Hannover). The results obtained in the first 100 children (65% were younger than 3 years) who received a liver graft at the University of Louvain Medical Center in Brussels between March 1, 1984 and July 31, 1988 are reported. The survival rates (79% at one year and 73% at three year) which do not differ with regard to the age, the indication of the technical modalities (whole liver or reduced size livers) are strongly influenced by the clinical condition (84% vs 50% at one year in elective and emergency transplantations respectively). One third of the 122 grafts transplanted by the authors were reduced livers harvested from older and often adult donors. This technique provides results of equal quality and does not entail an increased rate of technical complications; on the contrary, the incidence of arterial thrombosis has been significantly reduced. Transplantation of a reduced size liver is safe and should be recommended even in elective conditions, in view of the dire shortage of small pediatric donors.

摘要

在过去四年中,欧洲的小儿肝移植迅速发展。1987年12月31日欧洲登记处记录的254名15岁以下儿童的一年生存率为68%,三年生存率为61%;19个中心参与了此项工作,其中11个中心每个中心进行的病例少于5例,而三分之二的经验集中在三个中心(布鲁塞尔、剑桥、汉诺威)。本文报告了1984年3月1日至1988年7月31日期间在布鲁塞尔鲁汶大学医学中心接受肝移植的首批100名儿童(65%年龄小于3岁)的结果。生存率(一年时为79%,三年时为73%)在年龄、技术方式(全肝或减体积肝)指征方面无差异,但受临床状况的强烈影响(择期和急诊移植一年时分别为84%和50%)。作者移植的122例移植物中有三分之一是取自年龄较大且通常为成人供者的减体积肝。这项技术提供了同等质量的结果,且不会导致技术并发症发生率增加;相反,动脉血栓形成的发生率显著降低。鉴于小儿小供者严重短缺,即使在择期情况下,减体积肝移植也是安全的,应予以推荐。

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