Harch Paul G, Fogarty Edward F
Department of Medicine, Section of Emergency and Hyperbaric Medicine, Louisiana State University School of Medicine, New Orleans, LA, USA.
Department of Radiology, University of North Dakota School of Medicine and Health Sciences, Bismarck, ND, USA.
Med Gas Res. 2019 Jan 9;8(4):181-184. doi: 10.4103/2045-9912.248271. eCollection 2018 Oct-Dec.
A 58-year-old female was diagnosed with Alzheimer's dementia (AD) which was rapidly progressive in the 8 months prior to initiation of hyperbaric oxygen therapy (HBOT). Fluorodeoxyglucose (FDG) positron emission tomography (PET) brain imaging demonstrated global and typical metabolic deficits in AD (posterior temporal-parietal watershed and cingulate areas). An 8-week course of HBOT reversed the patient's symptomatic decline. Repeat PET imaging demonstrated a corresponding 6.5-38% regional and global increase in brain metabolism, including increased metabolism in the typical AD diagnostic areas of the brain. Continued HBOT in conjunction with standard pharmacotherapy maintained the patient's symptomatic level of function over an ensuing 22 months. This is the first reported case of simultaneous HBOT-induced symptomatic and FDG PET documented improvement of brain metabolism in AD and suggests an effect on global pathology in AD.
一名58岁女性被诊断为阿尔茨海默病性痴呆（AD），在开始高压氧治疗（HBOT）前的8个月里病情迅速进展。氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）脑成像显示AD存在典型的全脑代谢缺陷（颞顶叶后分水岭区和扣带区）。一个为期8周的HBOT疗程逆转了患者的症状性衰退。重复PET成像显示大脑代谢在区域和整体上相应增加了6.5%至38%，包括大脑典型AD诊断区域的代谢增加。在接下来的22个月里，持续的HBOT联合标准药物治疗维持了患者的症状性功能水平。这是首例报告的同时有HBOT诱导症状改善以及FDG PET记录显示AD脑代谢改善的病例，提示其对AD整体病理有影响。
